(Q33570999)

28 July 2017

title

Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement? (English)

1 reference

28 July 2017

Christopher J Endres

1

1 reference

28 July 2017

Michael G Endres

series ordinal

2

1 reference

28 July 2017

Jashvant D Unadkat

series ordinal

3

1 reference

28 July 2017

language of work or name

English

0 references

publication date

1 November 2009

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28 July 2017

published in

Molecular Pharmaceutics

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28 July 2017

volume

6

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28 July 2017

issue

6

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28 July 2017

page(s)

1756-1765

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Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells

28 July 2017

cites work

1 reference

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Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

21 June 2018

1 reference

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In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney

21 June 2018

1 reference

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Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans

21 June 2018

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Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

21 June 2018

1 reference

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Prediction of intestinal first-pass drug metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801584

Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake

21 June 2018

1 reference

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Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

21 June 2018

1 reference

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Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

21 June 2018

1 reference

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The roles of transporters and enzymes in hepatic drug processing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801584

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

21 June 2018

1 reference

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Clearance concepts in pharmacokinetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801584

Commentary: a physiological approach to hepatic drug clearance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801584

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices.

21 June 2018

1 reference

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Effects of uptake and efflux transporter inhibition on erythromycin breath test results

31 October 2018

1 reference

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In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay

31 October 2018

1 reference

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MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

31 October 2018

1 reference

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In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats

31 October 2018

1 reference

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Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801584

Organ clearance concepts: new perspectives on old principles.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801584

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs

31 October 2018

1 reference

12 December 2020

Effect of diffusional barriers on drug and metabolite kinetics

1 reference

12 December 2020

Membrane transport in hepatic clearance of drugs. I: Extended hepatic clearance models incorporating concentration-dependent transport and elimination processes

1 reference

12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

1 reference

12 December 2020

Identifiers

DOI

10.1021/MP9002392

1 reference

28 July 2017

1 reference

28 July 2017

1 reference