(Q37184530)

English

Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans

scientific article published on 07 June 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

1 reference

Europe PubMed Central

Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Satoshi Kitamura

1

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

Kazuya Maeda

2

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

Yuichi Sugiyama

3

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

publication date

7 June 2008

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

PubMed publication ID

18 August 2017

377

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

4-6

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

617-628

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

https://scigraph.springernature.com/pub.10.1007/s00210-008-0312-9

0 references

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of temocapril and enalapril in patients with various degrees of renal insufficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenomics of human OATP transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil greatly increases plasma concentrations of cerivastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Druggability: selecting optimized drug candidates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug transporters in pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of transporters in drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transporters as a determinant of drug clearance and tissue distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resista

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active efflux across the blood-brain barrier: role of the solute carrier family

1 reference

https://pubmed.ncbi.nlm.nih.gov/18536908

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-008-0312-9

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 August 2017

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