(Q36416907)

14 August 2017

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title

Pharmacogenomics of human OATP transporters (English)

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14 August 2017

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Jörg König

1

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14 August 2017

Annick Seithel

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2

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14 August 2017

Ulrike Gradhand

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3

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14 August 2017

Martin F Fromm

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4

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14 August 2017

9 March 2006

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Naunyn-Schmiedeberg's Archives of Pharmacology

14 August 2017

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14 August 2017

372

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14 August 2017

432-443

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14 August 2017

6

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https://scigraph.springernature.com/pub.10.1007/s00210-006-0040-y

14 August 2017

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cites work

Multispecific amphipathic substrate transport by an organic anion transporter of human liver.

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12 December 2020

Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins

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12 December 2020

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

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12 December 2020

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

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12 December 2020

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

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12 December 2020

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

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12 December 2020

Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes.

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12 December 2020

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

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12 December 2020

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

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12 December 2020

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

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12 December 2020

Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents.

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12 December 2020

Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain

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12 December 2020

Expression cloning of a rat liver Na(+)-independent organic anion transporter

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12 December 2020

Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

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12 December 2020

Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.

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12 December 2020

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

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12 December 2020

Identification of thyroid hormone transporters.

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12 December 2020

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

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12 December 2020

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

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12 December 2020

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

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12 December 2020

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

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12 December 2020

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

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12 December 2020

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

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12 December 2020

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

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12 December 2020

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

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12 December 2020

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

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12 December 2020

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

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12 December 2020

Identification of phalloidin uptake systems of rat and human liver

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12 December 2020

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

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12 December 2020

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

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12 December 2020

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

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12 December 2020

Hepatic uptake of the novel antifungal agent caspofungin

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12 December 2020

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

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12 December 2020

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

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12 December 2020

Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells.

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12 December 2020

Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver.

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12 December 2020

Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment

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12 December 2020

The MRP family of drug efflux pumps

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12 December 2020

A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy.

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12 December 2020

Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154.

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12 December 2020

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

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12 December 2020

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

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12 December 2020

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity

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12 December 2020

Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations.

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12 December 2020

Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin

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12 December 2020

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

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12 December 2020

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

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12 December 2020

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

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12 December 2020

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

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12 December 2020

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

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12 December 2020

Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin

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12 December 2020

Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin

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12 December 2020

Genetic factors related to unconjugated hyperbilirubinemia amongst adults

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12 December 2020

Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins

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12 December 2020

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

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12 December 2020

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

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12 December 2020

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

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12 December 2020

Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

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12 December 2020

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

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12 December 2020

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

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12 December 2020

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

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12 December 2020

Mammalian ABC transporters in health and disease

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12 December 2020

Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium.

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12 December 2020

Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner

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12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

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12 December 2020

Importance of P-glycoprotein at blood-tissue barriers

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12 December 2020

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

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12 December 2020

Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier

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12 December 2020

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

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12 December 2020

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

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12 December 2020

The superfamily of organic anion transporting polypeptides

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12 December 2020

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

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12 December 2020

The organic anion transporter (OATP) family.

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12 December 2020

Expression of organic anion transporting polypeptide E (OATP-E) in human placenta

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12 December 2020

10.1007/S00210-006-0040-Y

Identifiers

DOI

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14 August 2017

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