(Q33589249)

28 July 2017

1 reference

title

Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology (English)

1 reference

28 July 2017

0 references

0 references

Nalini M Rajamannan

1

1 reference

28 July 2017

publication date

23 October 2009

1 reference

American Journal of Physiology Heart and Circulatory Physiology

28 July 2017

published in

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28 July 2017

volume

298

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28 July 2017

issue

1

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28 July 2017

page(s)

H5-15

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Role of the MAPK/ERK pathway in valvular interstitial cell calcification

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats

21 June 2018

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Mitral valvular interstitial cells demonstrate regional, adhesional, and synthetic heterogeneity

21 June 2018

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21 June 2018

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Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis

21 June 2018

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Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

21 June 2018

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21 June 2018

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Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis

21 June 2018

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Distribution of SPARC during neovascularisation of degenerative aortic stenosis

21 June 2018

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Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?

21 June 2018

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Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation

21 June 2018

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Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway

21 June 2018

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Mutations in NOTCH1 cause aortic valve disease

21 June 2018

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Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation

21 June 2018

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A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis

21 June 2018

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Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve

21 June 2018

1 reference

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Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals

21 June 2018

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Atorvastatin decreases cellular proliferation and bone matrix expression in the hypercholesterolemic mitral valve

21 June 2018

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

21 June 2018

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Wnt signaling in osteoblasts and bone diseases

21 June 2018

1 reference

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Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Multilineage potential of cells from the artery wall.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

High bone mass in mice expressing a mutant LRP5 gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

High bone density due to a mutation in LDL-receptor-related protein 5

21 June 2018

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21 June 2018

1 reference

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Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Cholesterol in vascular and valvular calcification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

C-reactive protein is increased in patients with degenerative aortic valvular stenosis

21 June 2018

1 reference

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Vascular calcification and inorganic phosphate

21 June 2018

1 reference

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Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis

21 June 2018

1 reference

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The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Association between calcific aortic stenosis and hypercholesterolemia: is there a need for a randomized controlled trial of cholesterol-lowering therapy?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

A case-control investigation of the relation between hyperlipidaemia and calcific aortic valve stenosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Non-invasive assessment of aortic stenosis by Doppler ultrasound

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Anionic surface properties of aortic and mitral valve endothelium from New Zealand white rabbits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Porcine cardiac valvular subendothelial cells in culture: cell isolation and growth characteristics.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Development and progression of aortic valve stenosis: atherosclerosis risk factors--a causal relationship? A clinical morphologic study

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Noninvasive assessment of pressure drop in mitral stenosis by Doppler ultrasound

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study

21 June 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons

21 January 2018

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Case-controlled study to assess risk factors for aortic stenosis in congenitally bicuspid aortic valve

21 January 2018

1 reference

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Diabetes and hypercholesterolemia among patients with calcific aortic stenosis.

21 January 2018

1 reference

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Experimental aortic valve stenosis in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

The relation between homocysteine and calcific aortic valve stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Calcification and cellularity in human aortic heart valve tissue determine the differentiation of bone-marrow-derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Lowering plasma cholesterol levels halts progression of aortic valve disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Oestrogen receptor alpha gene polymorphism is related to aortic valve sclerosis in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Clinical factors, but not C-reactive protein, predict progression of calcific aortic-valve disease: the Cardiovascular Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Association Between Apolipoprotein E Alleles and Calcific Valvular Heart Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

New insights into the progression of aortic stenosis: implications for secondary prevention.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts: implications for end-stage valvular heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Lipid profile of patients with aortic stenosis might be predictive of rate of progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Role of human valve interstitial cells in valve calcification and their response to atorvastatin.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Development of aortic valve sclerosis in a rabbit model of atherosclerosis: an immunohistochemical and histological study.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Experimental hypercholesterolemia induces apoptosis in the aortic valve.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806146

Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis

31 October 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Mild and moderate aortic stenosis Natural history and risk stratification by echocardiography

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Association of Angiotensin-Converting Enzyme With Low-Density Lipoprotein in Aortic Valvular Lesions and in Human Plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Association of Aortic-Valve Sclerosis with Cardiovascular Mortality and Morbidity in the Elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00824.2009

Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification

21 January 2018

1 reference

12 December 2020

Familial aggregation of calcific aortic valve stenosis in the western part of France

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12 December 2020

C-reactive protein in predicting coronary artery disease in subjects with aortic valve sclerosis before diagnostic coronary angiography

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12 December 2020

A novel role of extracellular nucleotides in valve calcification: a potential target for atorvastatin

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12 December 2020

Stimulatory effects of atorvastatin on extracellular nucleotide degradation in human endothelial cells

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12 December 2020

Calcific aortic valve stenosis in old hypercholesterolemic mice

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12 December 2020

Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits

1 reference

12 December 2020

Bone formation in cardiac valves: a histopathological study of 128 cases

1 reference

12 December 2020

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12 December 2020

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

1 reference

12 December 2020

Case-control analysis of risk factors for presence of aortic stenosis in adults (age 50 years or older)

1 reference

12 December 2020

Bone formation and inflammation in cardiac valves

1 reference

12 December 2020

Relation between cardiovascular risk factors and nonrheumatic severe calcific aortic stenosis among patients with a three-cuspid aortic valve

1 reference

12 December 2020

[Influence of insertion-deletion polymorphism of the angiotensin converting enzyme gene on left ventricular hypertrophy in patients with aortic stenosis--differences in men and women]

1 reference

12 December 2020

Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification

1 reference

12 December 2020

Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity

1 reference

12 December 2020

Surface responses of aortic valve endothelia from diet-induced, hypercholesterolemic rabbits

1 reference

12 December 2020

Value and limitations of continuous-wave Doppler echocardiography in estimating severity of valvular stenosis

1 reference

12 December 2020

A cytochemical study of the surface properties of aortic and mitral valve endothelium from hypercholesterolemic rabbits

1 reference

12 December 2020

Correlation of serum lipids, calcium, and phosphorus, diabetes mellitus and history of systemic hypertension with presence or absence of calcified or thickened aortic cusps or root in elderly patients

1 reference

12 December 2020

Interactions of IgG and beta-VLDL with aortic valve endothelium from hypercholesterolemic rabbits

1 reference

12 December 2020

Factors associated with calcific aortic valve degeneration in the elderly

1 reference

12 December 2020

Osteopontin is expressed in human aortic valvular lesions

1 reference

12 December 2020

Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis

1 reference

12 December 2020

Detection of osteopontin in calcified human aortic valves

1 reference

12 December 2020

Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels

1 reference

12 December 2020

10.1152/AJPHEART.00824.2009

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference