(Q37592503)

21 August 2017

Role of the MAPK/ERK pathway in valvular interstitial cell calcification (English)

1 reference

21 August 2017

2

Kristyn S Masters

1 reference

21 August 2017

Xiaoxiao Gu

1

1 reference

21 August 2017

10 April 2009

1 reference

American Journal of Physiology Heart and Circulatory Physiology

21 August 2017

1 reference

21 August 2017

296

1 reference

21 August 2017

6

1 reference

21 August 2017

H1748-57

1 reference

PMC publication ID

5243218

describes a project that uses

21 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5243218/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Calcific aortic stenosis: lessons learned from experimental and clinical studies

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Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment

23 August 2017

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Statins stimulate RGS-regulated ERK 1/2 activation in human calcified and stenotic aortic valves

23 August 2017

1 reference

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The use of acellular matrices for the tissue engineering of cardiac valves.

23 August 2017

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Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves

23 August 2017

1 reference

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Integrin-mediated signalling through the MAP-kinase pathway.

23 August 2017

1 reference

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Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

23 August 2017

1 reference

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Transcriptional regulation of osteoblasts.

23 August 2017

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The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology

23 August 2017

1 reference

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Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

23 August 2017

1 reference

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Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more).

23 August 2017

1 reference

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Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation

23 August 2017

1 reference

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Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway

23 August 2017

1 reference

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Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor

23 August 2017

1 reference

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Small guanine nucleotide-binding protein Rho and myocardial function

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Mechanisms of aortic valve calcification

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Porcine aortic valve interstitial cells in three-dimensional culture: comparison of phenotype with aortic smooth muscle cells.

23 August 2017

1 reference

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Living artificial heart valve alternatives: a review.

23 August 2017

1 reference

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Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling

23 August 2017

1 reference

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The cardiac valve interstitial cell

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells

23 August 2017

1 reference

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Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Porcine cardiac valvular subendothelial cells in culture: cell isolation and growth characteristics.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Regulation of valvular interstitial cell calcification by components of the extracellular matrix

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Taurine inhibits osteoblastic differentiation of vascular smooth muscle cells via the ERK pathway

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Erk pathways negatively regulate matrix mineralization

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Fibronectin enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells via ERK pathway.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

ERK signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells on collagen I and vitronectin

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Activation of valvular interstitial cells is mediated by transforming growth factor-beta1 interactions with matrix molecules.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Calcification of bicuspid aortic valves

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Phenotypic modulation of arterial smooth muscle cells is associated with prolonged activation of ERK1/2.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5243218

Identification and characterization of calcifying valve cells from human and canine aortic valves

1 September 2018

1 reference

12 December 2020

Bone formation and inflammation in cardiac valves

1 reference

12 December 2020

Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification

1 reference

12 December 2020

Structural alterations in heart valves during left ventricular pressure overload in the rat

1 reference

12 December 2020

Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies

1 reference

12 December 2020

Extracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves

1 reference

12 December 2020

Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves

1 reference

12 December 2020

10.1152/AJPHEART.00099.2009

Identifiers

DOI

1 reference

21 August 2017

1 reference

PMC publication ID

5243218

21 August 2017

PubMed publication ID

19363136

1 reference

PMC publication ID

5243218