(Q33594234)

28 July 2017

title

An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6 (English)

1 reference

28 July 2017

6

Adrian V S Hill

1 reference

Jayachandran Radhakrishnan

28 July 2017

Jayachandran Radhakrishnan

3

0 references

Benjamin P Fairfax

Benjamin P Fairfax

1

0 references

Julian C Knight

Julian C Knight

7

0 references

Hakon Hakonarson

4

Hakon Hakonarson

1 reference

28 July 2017

Fredrik O Vannberg

2

1 reference

28 July 2017

Brendan J Keating

5

1 reference

28 July 2017

publication date

26 November 2009

1 reference

28 July 2017

published in

Human Molecular Genetics

1 reference

28 July 2017

volume

19

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28 July 2017

issue

4

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28 July 2017

page(s)

720-730

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12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice

28 July 2017

cites work

1 reference

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21 June 2018

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21 June 2018

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21 June 2018

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Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia

21 June 2018

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Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphism

21 June 2018

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The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages

21 June 2018

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21 June 2018

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Genetic and environmental contributions to plasma C-reactive protein and interleukin-6 levels--a study in twins

21 June 2018

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Inflammation and immune regulation by 12/15-lipoxygenases

21 June 2018

1 reference

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 June 2018

1 reference

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Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy.

21 June 2018

1 reference

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Mapping determinants of human gene expression by regional and genome-wide association

21 June 2018

1 reference

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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes

21 June 2018

1 reference

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Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Haploview: analysis and visualization of LD and haplotype maps

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Theoretical basis of the Beavis effect.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

The structure of haplotype blocks in the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

High-dose leptin activates human leukocytes via receptor expression on monocytes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Leptin regulates proinflammatory immune responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

TRANSFAC: a database on transcription factors and their DNA binding sites

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

The impact of interleukin-6 promoter -597/-572/-174genotype on interleukin-6 production after lipopolysaccharide stimulation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

The effects of calpain inhibition on IkB alpha degradation after activation of PBMCs: identification of the calpain cleavage sites

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Short-term variability in the concentration of serum interleukin-6 and its soluble receptor in subjectively healthy persons

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807371

Novel polymorphisms in the 5' region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity

30 October 2018

1 reference

12 December 2020

Heritability estimates of innate immunity: an extended twin study

1 reference

12 December 2020

IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women

1 reference

12 December 2020

Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica

1 reference

12 December 2020

Genetic variation in the interleukin-6 gene in relation to risk and outcomes in acute coronary syndrome

1 reference

12 December 2020

Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes

1 reference

12 December 2020

The interleukin-6 (IL6)-174 G/C promoter genotype is associated with the presence of septic shock and the ex vivo secretion of IL6

1 reference

12 December 2020

Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDP530

1 reference

28 July 2017

1 reference

28 July 2017

1 reference