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Function and biological applications of catalytic nucleic acids
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Function and biological applications of catalytic nucleic acids
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
author name string
D J Gaughan
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
A S Whitehead
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
language of work or name
English
0 references
publication date
1 April 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
number of pages
20
1 reference
based on heuristic
inferred from page(s)
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
volume
1445
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
page(s)
1-20
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
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The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
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A site-specific self-cleavage reaction performed by a novel RNA in Neurospora mitochondria
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Effective ribozyme delivery in plant cells
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Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint
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Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.
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A ribozyme-mediated, gene "knockdown" strategy for the identification of gene function in zebrafish
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Ribozyme mediated destruction of RNA in vivo
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A small catalytic oligoribonucleotide
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Numbering system for the hammerhead
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Three-dimensional structure of a hammerhead ribozyme
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The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage
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Simple RNA enzymes with new and highly specific endoribonuclease activities
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Sequence requirements of the hammerhead RNA self-cleavage reaction
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Small catalytic RNAs
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Compilation of self-cleaving sequences from plant virus satellite RNAs and other sources
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Design of RNA enzymes distinguishing a single base mutation in RNA.
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Extended target-site specificity for a hammerhead ribozyme
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Generality of the NUX rule: kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of hammerhead ribozymes
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In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme
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In vitro selection of RNA molecules that bind specific ligands
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Ribozymes: a distinct class of metalloenzymes
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Role of divalent metal ions in the hammerhead RNA cleavage reaction
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Magnesium-mediated conversion of an inactive form of a hammerhead ribozyme to an active complex with its substrate. An investigation by NMR spectroscopy
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Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation.
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Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme
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The structural basis of hammerhead ribozyme self-cleavage
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Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb
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Metal ions play a passive role in the hairpin ribozyme catalysed reaction
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Can hammerhead ribozymes be efficient tools to inactivate gene function?
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Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information
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Ribozyme mediated cleavage of acute phase serum amyloid A (A-SAA) mRNA in vitro
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Selection of efficient cleavage sites in target RNAs by using a ribozyme expression library
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7 January 2021
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Adenovirus-mediated expression of ribozymes in mice.
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7 January 2021
based on heuristic
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Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Improved accumulation and activity of ribozymes expressed from a tRNA-based RNA polymerase III promoter.
1 reference
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7 January 2021
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Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors
1 reference
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reference URL
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7 January 2021
based on heuristic
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Construction of a tRNA-embedded-ribozyme trimming plasmid
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of HIV-specific ribozyme activity by self-cleavage
1 reference
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7 January 2021
based on heuristic
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Importance of independence in ribozyme reactions: kinetic behavior of trimmed and of simply connected multiple ribozymes with potential activity against human immunodeficiency virus
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
A multifunctional expression vector for an anti-HIV-1 ribozyme that produces a 5'- and 3'-trimmed trans-acting ribozyme, targeted against HIV-1 RNA, and cis-acting ribozymes that are designed to bind to and thereby sequester trans-activator proteins
1 reference
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reference URL
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7 January 2021
based on heuristic
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Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1
1 reference
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7 January 2021
based on heuristic
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Protein enhancement of hammerhead ribozyme catalysis
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7 January 2021
based on heuristic
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Interaction between tumour necrosis factor alpha ribozyme and cellular proteins. Involvement in ribozyme stability and activity
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7 January 2021
based on heuristic
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Enhancement of hammerhead ribozyme catalysis by glyceraldehyde-3-phosphate dehydrogenase
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7 January 2021
based on heuristic
inferred from DOI database lookup
The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro
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7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Modified deoxyoligonucleotides stable to exonuclease degradation in serum
1 reference
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7 January 2021
based on heuristic
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A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo
1 reference
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7 January 2021
based on heuristic
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Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages
1 reference
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Crossref
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7 January 2021
based on heuristic
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Specific hammerhead ribozyme-mediated cleavage of mutant N-ras mRNA in vitro and ex vivo. Oligoribonucleotides as therapeutic agents
1 reference
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7 January 2021
based on heuristic
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Human gene therapy
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7 January 2021
based on heuristic
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Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter
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7 January 2021
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Site-specific integration by adeno-associated virus
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7 January 2021
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The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications
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Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozymes as potential anti-HIV-1 therapeutic agents.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme targeting of HIV-1 LTR.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated suppression of Moloney murine leukemia virus and human immunodeficiency virus type I replication in permissive cell lines
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
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The accuracy of reverse transcriptase from HIV-1.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of HIV-1 replication by retroviral vectors expressing monomeric and multimeric hammerhead ribozymes
1 reference
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Crossref
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7 January 2021
based on heuristic
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Molecular pathogenesis of Ph-positive leukemias
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7 January 2021
based on heuristic
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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective cleavage of bcr-abl chimeric RNAs by a ribozyme targeted to non-contiguous sequences
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of collagen RNA transcripts by hammerhead ribozymes in vitro is mutation-specific and shows competitive binding effects
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Self-splicing of group I introns
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated trans-splicing of a trinucleotide repeat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated suppression of the G protein gamma7 subunit suggests a role in hormone regulation of adenylylcyclase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900021-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0167-4781(99)00021-4
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
PubMed ID
10209254
1 reference
stated in
Europe PubMed Central
PubMed ID
10209254
retrieved
28 July 2017
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