(Q33598692)

28 July 2017

title

4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. (English)

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28 July 2017

Brian A Lanman

6

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author name string

Lewis D Pennington

1

1 reference

28 July 2017

Kelvin K C Sham

2

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28 July 2017

Alexander J Pickrell

3

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28 July 2017

Paul E Harrington

4

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28 July 2017

Michael J Frohn

5

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28 July 2017

Anthony B Reed

7

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28 July 2017

Michael D Croghan

8

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28 July 2017

Matthew R Lee

9

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28 July 2017

Han Xu

10

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28 July 2017

Michele McElvain

11

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28 July 2017

Yang Xu

12

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28 July 2017

Xuxia Zhang

13

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28 July 2017

Michael Fiorino

14

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28 July 2017

Michelle Horner

15

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28 July 2017

Henry G Morrison

16

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28 July 2017

Heather A Arnett

17

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28 July 2017

Christopher Fotsch

18

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28 July 2017

Min Wong

19

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28 July 2017

Victor J Cee

20

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28 July 2017

publication date

29 July 2011

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ACS Medicinal Chemistry Letters

28 July 2017

published in

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28 July 2017

volume

2

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28 July 2017

issue

10

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28 July 2017

page(s)

752-757

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Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Sphingosine 1-phosphate receptor signaling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

The alliance of sphingosine-1-phosphate and its receptors in immunity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Identification of the hydrophobic ligand binding pocket of the S1P1 receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

The preparation of some 4-substituted nicotinic acids and nicotinamides.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018088

The reaction of amides with isocyanates

30 October 2018

1 reference

12 December 2020

FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects

1 reference

12 December 2020

The Metabolism of Arylthioureas--II. The Metabolism of 14C- and 35S-Labelled 1-Phenyl-2-Thiourea and its Derivatives

1 reference

12 December 2020

Degradation study of the investigational anticancer drug clanfenur

1 reference

12 December 2020

Identifiers

DOI

10.1021/ML2001399

1 reference

28 July 2017

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28 July 2017

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