(Q33601747)

28 July 2017

title

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production (English)

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28 July 2017

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Deborah A Fraser

1

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28 July 2017

Karntipa Pisalyaput

series ordinal

2

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28 July 2017

Andrea J Tenner

series ordinal

3

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28 July 2017

language of work or name

English

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publication date

16 November 2009

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Journal of Neurochemistry

28 July 2017

published in

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28 July 2017

volume

112

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28 July 2017

issue

3

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28 July 2017

page(s)

733-743

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C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

21 June 2018

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IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells

21 June 2018

1 reference

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Interleukin-10: new perspectives on an old cytokine

21 June 2018

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C1q: the perfect complement for a synaptic feast?

21 June 2018

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Microglial clearance function in health and disease

21 June 2018

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The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis.

21 June 2018

1 reference

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Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

The classical complement cascade mediates CNS synapse elimination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Engulfment of apoptotic cells: signals for a good meal

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Role of complement and complement regulators in the removal of apoptotic cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

The double-edged flower: roles of complement protein C1q in neurodegenerative diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Role of complement and other innate immune mechanisms in the removal of apoptotic cells

21 June 2018

1 reference

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CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

21 June 2018

1 reference

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C1q, autoimmunity and apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Complement component C1q modulates the phagocytosis of Abeta by microglia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microglia-mediated neurotoxicity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophagesin vitro

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

30 October 2018

1 reference

12 December 2020

Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity

1 reference

12 December 2020

C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement Attack

1 reference

12 December 2020

C4b-binding protein in Alzheimer's disease: Binding to Aβ1–42 and to dead cells

1 reference

12 December 2020

The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells

1 reference

12 December 2020

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

1 reference

12 December 2020

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells

1 reference

12 December 2020

Chronically stimulated microglial cells do no longer alter their immune functions in response to the phagocytosis of apoptotic cells

1 reference

12 December 2020

Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma

1 reference

12 December 2020

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

1 reference

12 December 2020

10.1111/J.1471-4159.2009.06494.X

Identifiers

DOI

1 reference

28 July 2017

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28 July 2017

1 reference