(Q33610437)

English

PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer (English)

1 reference

Europe PubMed Central

28 July 2017

estrogen-receptor positive breast cancer

0 references

1 reference

based on heuristic

inferred from title

Charles M. Perou

6

1 reference

Europe PubMed Central

28 July 2017

author name string

Robert J Crowder

1

1 reference

Europe PubMed Central

28 July 2017

Chanpheng Phommaly

2

1 reference

Europe PubMed Central

28 July 2017

Yu Tao

3

1 reference

Europe PubMed Central

28 July 2017

Jeremy Hoog

4

1 reference

Europe PubMed Central

28 July 2017

Jingqin Luo

5

1 reference

Europe PubMed Central

28 July 2017

Joel S Parker

7

1 reference

Europe PubMed Central

28 July 2017

Melinda A Miller

8

1 reference

Europe PubMed Central

28 July 2017

David G Huntsman

9

1 reference

Europe PubMed Central

28 July 2017

Li Lin

10

1 reference

Europe PubMed Central

28 July 2017

Jacqueline Snider

11

1 reference

Europe PubMed Central

28 July 2017

Sherri R Davies

12

1 reference

Europe PubMed Central

28 July 2017

John A Olson

13

1 reference

Europe PubMed Central

28 July 2017

Mark A Watson

14

1 reference

Europe PubMed Central

28 July 2017

Anthony Saporita

15

1 reference

Europe PubMed Central

28 July 2017

Jason D Weber

16

1 reference

Europe PubMed Central

28 July 2017

Matthew J Ellis

17

1 reference

Europe PubMed Central

28 July 2017

language of work or name

0 references

publication date

14 April 2009

1 reference

Europe PubMed Central

28 July 2017

Cancer Research

1 reference

Europe PubMed Central

28 July 2017

69

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Europe PubMed Central

28 July 2017

9

1 reference

Europe PubMed Central

28 July 2017

3955-3962

1 reference

Europe PubMed Central

28 July 2017

Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Supervised risk predictor of breast cancer based on intrinsic subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

ESR1 gene amplification in breast cancer: a common phenomenon?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Targeting phosphoinositide 3-kinase: moving towards therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Downregulation of PIK3CB by siRNA suppresses malignant glioma cell growth in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Exploiting the PI3K/AKT pathway for cancer drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Multiple genes at 17q23 undergo amplification and overexpression in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

21 June 2018

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

PIK3CA mutations in breast cancer are associated with poor outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

Short-term changes in Ki-67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811393

30 October 2018

Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19366795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-related effects of estrogen withdrawal on proliferation- and cell death-related events in MCF-7 xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19366795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women

1 reference

https://pubmed.ncbi.nlm.nih.gov/19366795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19366795

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-4450

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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