(Q33618542)

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HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality

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Europe PubMed Central

PubMed publication ID

28 July 2017

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality (English)

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PubMed publication ID

28 July 2017

anti-retroviral agent

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T cell activation

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Sergio Serrano-Villar

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Sergio Serrano-Villar

1

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Barbara L Shacklett

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Barbara L Shacklett

6

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Frederick M. Hecht

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Frederick M Hecht

17

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21

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Steven G Deeks

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28 July 2017

Joseph M McCune

19

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Joseph M McCune

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28 July 2017

Michael M Lederman

13

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Michael M Lederman

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28 July 2017

Priscilla Y Hsue

10

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Priscilla Y Hsue

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28 July 2017

3

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Sulggi A Lee

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28 July 2017

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April L Ferre

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28 July 2017

11

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Mark L Van Natta

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28 July 2017

Curtis L. Meinert

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Curtis L Meinert

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28 July 2017

14

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Hiroyu Hatano

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28 July 2017

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Talia Sainz

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28 July 2017

Peter W Hunt

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28 July 2017

Elizabeth Sinclair

5

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28 July 2017

Timothy L Hayes

8

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28 July 2017

Ma Somsouk

9

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28 July 2017

Vivek Jain

15

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28 July 2017

Yong Huang

16

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28 July 2017

Jeffrey N Martin

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28 July 2017

Santiago Moreno

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28 July 2017

publication date

15 May 2014

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28 July 2017

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28 July 2017

10

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28 July 2017

5

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28 July 2017

e1004078

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Europe PubMed Central

PubMed publication ID

28 July 2017

copyright license

Creative Commons Attribution 4.0 International

15 May 2014

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April 2022 Public Data File from Crossref

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Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging

1 reference

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21 June 2018

Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Systemic effects of inflammation on health during chronic HIV infection

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21 June 2018

The CD4:CD8 ratio is associated with markers of age-associated disease in virally suppressed HIV-infected patients with immunological recovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers

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21 June 2018

Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism

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21 June 2018

The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial

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The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

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21 June 2018

Long-term suppressive combined antiretroviral treatment does not normalize the serum level of soluble CD14.

1 reference

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21 June 2018

Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells

1 reference

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21 June 2018

Inflammation, coagulation and cardiovascular disease in HIV-infected individuals

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Arterial inflammation in patients with HIV.

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21 June 2018

Immunosenescence and HIV.

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21 June 2018

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

AIDS and non-AIDS morbidity and mortality across the spectrum of CD4 cell counts in HIV-infected adults before starting antiretroviral therapy in Cote d'Ivoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Factors influencing the normalization of CD4+ T-cell count, percentage and CD4+/CD8+ T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

HIV Infection, Inflammation, Immunosenescence, and Aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Early immune senescence in HIV disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Mortality of HIV-infected patients starting potent antiretroviral therapy: comparison with the general population in nine industrialized countries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Inflammatory and coagulation biomarkers and mortality in patients with HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Collagen deposition limits immune reconstitution in the gut

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Changes in the risk of death after HIV seroconversion compared with mortality in the general population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

1 reference

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21 June 2018

Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4022662

21 June 2018

Survival of persons with and without HIV infection in Denmark, 1995-2005.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Premature age-related comorbidities among HIV-infected persons compared with the general population

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Failure of T-cell homeostasis preceding AIDS in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Impact of inversion of the CD4/CD8 ratio on the natural history of HIV-1 infection.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Optimization of methods to assess human mucosal T-cell responses to HIV infection.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

All-cause mortality in treated HIV-infected adults with CD4 ≥500/mm3 compared with the general population: evidence from a large European observational cohort collaboration

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1004078

21 January 2018

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

1 reference

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30 October 2018

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts

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https://pubmed.ncbi.nlm.nih.gov/24831517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24831517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population

1 reference

https://pubmed.ncbi.nlm.nih.gov/24831517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24831517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PPAT.1004078

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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