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Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
title
Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization
(English)
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
main subject
protein heterodimerization activity
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author
Veli-Matti Leppänen
series ordinal
1
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Europe PubMed Central
PMC publication ID
5410806
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
author name string
Pipsa Saharinen
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2
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
Kari Alitalo
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3
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
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17 March 2020
language of work or name
English
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publication date
10 April 2017
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Europe PubMed Central
PMC publication ID
5410806
reference URL
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retrieved
17 March 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
volume
114
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
issue
17
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
page(s)
4376-4381
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Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
describes a project that uses
ImageJ
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5410806/fullTextXML
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Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin
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A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner
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The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.
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Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
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21 June 2018
Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.
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Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner
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Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands
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Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1
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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
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21 June 2018
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
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21 June 2018
Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.
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21 June 2018
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
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21 June 2018
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21 June 2018
Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex
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21 June 2018
Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1.
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21 June 2018
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
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21 June 2018
Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.
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PubMed Central
reference URL
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21 June 2018
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity
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21 June 2018
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410806
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21 June 2018
Angiopoietin-1 protects the adult vasculature against plasma leakage.
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21 June 2018
Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity
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21 June 2018
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
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21 June 2018
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
1 reference
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21 June 2018
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410806
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21 June 2018
Putative tyrosine kinases expressed in K-562 human leukemia cells
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21 June 2018
A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains
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21 June 2018
Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report
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Crossref
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https://api.crossref.org/works/10.1073%2FPNAS.1616166114
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21 January 2018
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
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Crossref
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21 January 2018
Structure of the Extracellular Domain of Tie Receptor Tyrosine Kinases and Localization of the Angiopoietin-binding Epitope
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Crossref
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21 January 2018
Signal transduction by vascular endothelial growth factor receptors
1 reference
stated in
PubMed
reference URL
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.1616166114
1 reference
stated in
Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
PMC publication ID
5410806
1 reference
stated in
Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
PubMed publication ID
28396439
1 reference
stated in
Europe PubMed Central
PMC publication ID
5410806
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28396439%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 March 2020
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