(Q33621745)

28 July 2017

title

Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis (English)

1 reference

28 July 2017

0 references

1 reference

Claire M Payne

1

1 reference

28 July 2017

Cheray Crowley-Skillicorn

2

1 reference

28 July 2017

Hana Holubec

3

1 reference

28 July 2017

Katerina Dvorak

4

1 reference

28 July 2017

Carol Bernstein

5

1 reference

28 July 2017

Mary Pat Moyer

6

1 reference

28 July 2017

Harinder Garewal

7

1 reference

28 July 2017

Harris Bernstein

8

1 reference

28 July 2017

publication date

10 May 2009

1 reference

28 July 2017

published in

Journal of toxicology

1 reference

28 July 2017

volume

2009

1 reference

28 July 2017

page(s)

785907

1 reference

Creative Commons Attribution 3.0 Unported

28 July 2017

copyright license

start time

1 January 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.

21 June 2018

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Organization of the pre-autophagosomal structure responsible for autophagosome formation

21 June 2018

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21 June 2018

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Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

21 June 2018

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Regulation of macroautophagy by mTOR and Beclin 1 complexes

21 June 2018

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Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

21 June 2018

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Autophagosome formation: core machinery and adaptations

21 June 2018

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Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein

21 June 2018

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ROS, mitochondria and the regulation of autophagy

21 June 2018

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21 June 2018

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Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells

21 June 2018

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

21 June 2018

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Lipid trafficking defects increase Beclin-1 and activate autophagy in Niemann-Pick type C disease

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Protein turnover via autophagy: implications for metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Hydrophobic bile salts trigger ceramide formation through endosomal acidification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Autophagy is activated for cell survival after endoplasmic reticulum stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Autophagy delays apoptotic death in breast cancer cells following DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Deoxycholate induces mitochondrial oxidative stress and activates NF-kappaB through multiple mechanisms in HCT-116 colon epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Autophagy signaling and the cogwheels of cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Apoptosis of human colon carcinoma HT-29 cells induced by ceramide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Oxidative stress and autophagy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Assessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Eating oneself and uninvited guests: autophagy-related pathways in cellular defense

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Inhibition of macroautophagy triggers apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Bile acids as carcinogens in human gastrointestinal cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Methods for monitoring autophagy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Role of mitochondrial permeability transition pores in mitochondrial autophagy.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Regulation and role of autophagy in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Molecular dissection of autophagy: two ubiquitin-like systems

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Multifunctional antioxidant activity of HBED iron chelator

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Housekeeping genes commanded to commit suicide in CpG-cleavage commitment upstream of Bcl-2 inhibition in caspase-dependent and -independent pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Shift from a mixed to a lactovegetarian diet: influence on acidic lipids in fecal water--a potential risk factor for colon cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Hypotheses for the etiology of colorectal cancer--an overview

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814131

Mitochondrial perturbation attenuates bile acid-induced cytotoxicity

21 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Unique dietary-related mouse model of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Genotoxic effect of bile acids on human normal and tumour colon cells and protection by dietary antioxidants and butyrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Caspase-6 mediated cleavage of guanylate cyclase alpha 1 during deoxycholate-induced apoptosis: protective role of the nitric oxide signaling module

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

ER-phagy: selective autophagy of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Autophagy: many paths to the same end.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Beryllium-stimulated reactive oxygen species and macrophage apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Beneficial effects of MnTBAP, a broad-spectrum reactive species scavenger, in rat renal ischemia/reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

A proteomic study of resistance to deoxycholate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Reactive oxygen species production by mitochondria in endothelial cells exposed to reoxygenation after hypoxia and glucose depletion is mediated by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Effects of oxaliplatin and 5-fluorouracil on the healing of colon anastomoses

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Deoxycholic Acid Induces Intracellular Signaling through Membrane Perturbations

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Shaping membranes into autophagosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2009%2F785907

Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers

21 January 2018

1 reference

12 December 2020

Increased susceptibility of cells to inducible apoptosis during growth from early to late log phase: an important caveat for in vitro apoptosis research

1 reference

12 December 2020

Antitumor effect of a copper coordination compound with superoxide dismutase-like activity

1 reference

12 December 2020

Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas

1 reference

12 December 2020

Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression

1 reference

12 December 2020

The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells

1 reference

12 December 2020

The stress-response proteins poly(ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis

1 reference

12 December 2020

Role of nitric oxide and peroxynitrite in bile salt-induced apoptosis: relevance to colon carcinogenesis

1 reference

12 December 2020

Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of anti-oxidants in Barrett's oesophagus

1 reference

12 December 2020

Reactive oxygen species activate focal adhesion kinase, paxillin and p130cas tyrosine phosphorylation in endothelial cells

1 reference

12 December 2020

Autophagy and cancer therapy

1 reference

12 December 2020

Identifiers

DOI

10.1155/2009/785907

1 reference

28 July 2017

1 reference

28 July 2017

1 reference