(Q48117471)

8 February 2018

title

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. (English)

1 reference

8 February 2018

1 reference

Jin Yu

1

1 reference

8 February 2018

Sergei A Novgorodov

2

1 reference

8 February 2018

Daria Chudakova

3

1 reference

8 February 2018

Hong Zhu

4

1 reference

8 February 2018

Alicja Bielawska

5

1 reference

8 February 2018

Jacek Bielawski

6

1 reference

8 February 2018

Lina M Obeid

7

1 reference

8 February 2018

Mark S Kindy

8

1 reference

8 February 2018

Tatyana I Gudz

9

1 reference

8 February 2018

language of work or name

English

0 references

publication date

3 July 2007

1 reference

8 February 2018

Journal of Biological Chemistry

published in

1 reference

8 February 2018

volume

282

1 reference

8 February 2018

issue

35

1 reference

8 February 2018

page(s)

25940-25949

1 reference

8 February 2018

Excitotoxins in neuronal apoptosis and necrosis

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Future targets and cascades for neuroprotective strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The Effect of Ischemia on Mitochondrial Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Biochemical changes associated with selective neuronal death following short-term cerebral ischaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Mitochondrial respiratory function and cell death in focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Mitochondrial contributions to tissue damage in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

A critical role of neural-specific JNK3 for ischemic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The ins and outs of sphingolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Biologically active sphingolipids in cancer pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Sphingolipids and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

An update of the enzymology and regulation of sphingomyelin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Carbohydrate analysis of glycoprotein hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER : A Morphological and Biochemical Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Kinase signaling cascades in the mitochondrion: a matter of life or death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Mechanisms of programmed cell death in the developing brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701812200

21 January 2018

Identifiers

DOI

10.1074/JBC.M701812200

1 reference

8 February 2018

PubMed ID

17609208

1 reference

8 February 2018