(Q45270341)

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Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 December 2017

Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Yanqin Gao

1

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Armando P Signore

2

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Wei Yin

3

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Guodong Cao

4

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Xiao-Ming Yin

5

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Fengyan Sun

6

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Yumin Luo

7

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Steven H Graham

8

1 reference

Europe PubMed Central

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11 December 2017

Jun Chen

9

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

language of work or name

1 reference

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publication date

1 June 2005

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Journal of Cerebral Blood Flow & Metabolism

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

694-712

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

1 reference

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21 January 2018

Expression of c-fos and c-jun family genes after focal cerebral ischemia

1 reference

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21 January 2018

The specificities of protein kinase inhibitors: an update

1 reference

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21 January 2018

Identification of the critical features of a small peptide inhibitor of JNK activity

1 reference

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21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

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21 January 2018

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

1 reference

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21 January 2018

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

1 reference

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21 January 2018

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

1 reference

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21 January 2018

Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia.

1 reference

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21 January 2018

Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death

1 reference

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21 January 2018

AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties

1 reference

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21 January 2018

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

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21 January 2018

Transient forebrain ischemia in the adult gerbil is associated with a complex c-Jun response.

1 reference

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21 January 2018

Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat.

1 reference

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21 January 2018

Programmed cell death in cerebral ischemia

1 reference

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21 January 2018

Bcl-2 family gene products in cerebral ischemia and traumatic brain injury

1 reference

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21 January 2018

Humanin peptide suppresses apoptosis by interfering with Bax activation

1 reference

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21 January 2018

Transcription factor ATF2 regulation by the JNK signal transduction pathway

1 reference

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21 January 2018

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

1 reference

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21 January 2018

c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion

1 reference

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21 January 2018

AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration

1 reference

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21 January 2018

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

Alteration of MAP kinase pathways after transient forebrain ischemia

1 reference

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21 January 2018

Role of mitogen- and stress-activated kinases in ischemic injury

1 reference

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21 January 2018

Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling.

1 reference

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21 January 2018

A critical role of neural-specific JNK3 for ischemic apoptosis

1 reference

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21 January 2018

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

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21 January 2018

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

1 reference

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21 January 2018

Targeting JNK for therapeutic benefit: from junk to gold?

1 reference

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21 January 2018

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1 reference

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21 January 2018

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

1 reference

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21 January 2018

Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

1 reference

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21 January 2018

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

1 reference

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21 January 2018

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

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21 January 2018

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

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21 January 2018

The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax

1 reference

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21 January 2018

A convoluted way to die.

1 reference

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21 January 2018

c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis

1 reference

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21 January 2018

AP-1 as a regulator of cell life and death

1 reference

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21 January 2018

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

1 reference

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21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

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21 January 2018

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

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21 January 2018

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

21 January 2018

Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia

1 reference

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21 January 2018

Apoptosis in the nervous system

1 reference

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21 January 2018

A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia.

1 reference

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21 January 2018

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia

1 reference

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7 January 2021

based on heuristic

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Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia

1 reference

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7 January 2021

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Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective agent chlomethiazole attenuates c-fos, c-jun, and AP-1 activation through inhibition of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p38MAPK in microglia after ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.JCBFM.9600062

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

ResearchGate publication ID

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