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The PIK-related kinases intercept conventional signaling pathways
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scholarly article
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Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
review article
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Europe PubMed Central
title
The PIK-related kinases intercept conventional signaling pathways
(English)
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Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
author name string
Kuruvilla FG
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
10322127
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28 July 2017
Schreiber SL
series ordinal
2
1 reference
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Europe PubMed Central
PubMed ID
10322127
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28 July 2017
publication date
1 May 1999
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Europe PubMed Central
PubMed ID
10322127
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28 July 2017
published in
Chemistry and Biology
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Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
volume
6
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Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
page(s)
R129-36
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Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
issue
5
1 reference
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Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
cites work
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
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A mammalian protein targeted by G1-arresting rapamycin-receptor complex
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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
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A single ataxia telangiectasia gene with a product similar to PI-3 kinase
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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
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PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
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DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
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The Schizosaccharomyces pombe rad3 checkpoint gene
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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
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An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
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TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.
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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
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7 January 2021
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The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily
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The ATM-related cofactor Tra1 is a component of the purified SAGA complex
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inferred from DOI database lookup
Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes.
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
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inferred from DOI database lookup
The modular phosphorylation and activation of p70s6k.
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7 January 2021
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Multiple independent inputs are required for activation of the p70 S6 kinase
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7 January 2021
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Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.
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7 January 2021
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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
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Alpha 4 associates with protein phosphatases 2A, 4, and 6
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7 January 2021
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Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
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Rapamycin resistance tied to defective regulation of p27Kip1.
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
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TOR controls translation initiation and early G1 progression in yeast
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Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
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Enhanced phosphorylation of p53 by ATM in response to DNA damage
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7 January 2021
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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
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p53, the cellular gatekeeper for growth and division
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A role for ATR in the DNA damage-induced phosphorylation of p53
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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A sense-abl response?
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7 January 2021
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Nuclear tyrosine kinases: from Abl to WEE1.
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7 January 2021
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rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.
1 reference
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7 January 2021
based on heuristic
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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
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The 14-3-3 proteins positively regulate rapamycin-sensitive signaling
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7 January 2021
based on heuristic
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HEAT repeats in the Huntington's disease protein
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7 January 2021
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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
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7 January 2021
based on heuristic
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Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
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Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Atm-deficient mice: a paradigm of ataxia telangiectasia
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
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The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of DNA-dependent protein kinase: implications for its regulation by DNA.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dual roles of ATM in the cellular response to radiation and in cell growth control.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1074-5521(99)80070-2
1 reference
stated in
Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
PubMed ID
10322127
1 reference
stated in
Europe PubMed Central
PubMed ID
10322127
retrieved
28 July 2017
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