(Q33632328)

28 July 2017

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title

The PIK-related kinases intercept conventional signaling pathways (English)

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28 July 2017

Kuruvilla FG

1

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28 July 2017

Schreiber SL

series ordinal

2

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28 July 2017

publication date

1 May 1999

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28 July 2017

published in

Chemistry and Biology

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28 July 2017

volume

6

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28 July 2017

issue

5

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28 July 2017

page(s)

R129-36

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

28 July 2017

cites work

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7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

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7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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7 January 2021

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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7 January 2021

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

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7 January 2021

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The Schizosaccharomyces pombe rad3 checkpoint gene

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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

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https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily

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7 January 2021

1 reference

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7 January 2021

Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes.

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7 January 2021

The modular phosphorylation and activation of p70s6k.

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7 January 2021

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

α4 Associates with Protein Phosphatases 2A, 4, and 6

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Rapamycin resistance tied to defective regulation of p27Kip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

TOR controls translation initiation and early G1 progression in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

A sense-abl response?

1 reference

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7 January 2021

Nuclear tyrosine kinases: from Abl to WEE1.

1 reference

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7 January 2021

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.

1 reference

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7 January 2021

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

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7 January 2021

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The 14-3-3 proteins positively regulate rapamycin-sensitive signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

HEAT repeats in the Huntington's disease protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Amino acids stimulate phosphorylation of p70 S6k and organization of rat adipocytes into multicellular clusters

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980070-2

7 January 2021

10.1016/S1074-5521(99)80070-2

Identifiers

DOI

1 reference

28 July 2017

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