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Rapamycin resistance tied to defective regulation of p27Kip1.
scientific article published on December 1996
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scholarly article
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stated in
Europe PubMed Central
PMCID
231677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
title
Rapamycin resistance tied to defective regulation of p27Kip1
(English)
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stated in
Europe PubMed Central
PMCID
231677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
main subject
sirolimus
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inferred from title
author
Joan Massagué Solé
series ordinal
5
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Europe PubMed Central
PMCID
231677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
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21 October 2019
author name string
Y Luo
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1
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Europe PubMed Central
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231677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
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21 October 2019
S O Marx
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2
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231677
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21 October 2019
H Kiyokawa
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3
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231677
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21 October 2019
A Koff
series ordinal
4
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PMCID
231677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
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21 October 2019
A R Marks
series ordinal
6
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231677
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21 October 2019
language of work or name
English
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publication date
1 December 1996
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231677
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21 October 2019
published in
Molecular and Cellular Biology
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231677
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21 October 2019
volume
16
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Europe PubMed Central
PMCID
231677
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retrieved
21 October 2019
page(s)
6744-6751
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Europe PubMed Central
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231677
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21 October 2019
issue
12
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Europe PubMed Central
PMCID
231677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
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21 October 2019
cites work
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
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PubMed Central
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30 September 2017
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.
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PubMed Central
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30 September 2017
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling
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30 September 2017
Translational control of p27Kip1 accumulation during the cell cycle
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30 September 2017
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.
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30 September 2017
Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
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30 September 2017
Structural and functional analysis of pp70S6k
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30 September 2017
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
1 reference
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PubMed Central
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30 September 2017
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
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30 September 2017
p53 and E2F-1 cooperate to mediate apoptosis
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30 September 2017
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
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PubMed Central
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30 September 2017
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Principles of CDK regulation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
p70s6k/p85s6k: mechanism of activation and role in mitogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Inhibitors of mammalian G1 cyclin-dependent kinases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
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PubMed Central
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30 September 2017
Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
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PubMed Central
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30 September 2017
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
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PubMed Central
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30 September 2017
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
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PubMed Central
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30 September 2017
Characterization of a unique muscle cell line
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PubMed Central
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30 September 2017
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
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PubMed Central
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30 September 2017
Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
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30 September 2017
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
1 reference
stated in
PubMed Central
reference URL
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1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
30 September 2017
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
30 September 2017
Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation
1 reference
stated in
PubMed Central
reference URL
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Control of p70 s6 kinase by kinase activity of FRAP in vivo
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
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30 September 2017
Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
28 June 2018
TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
28 June 2018
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
28 June 2018
Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
28 June 2018
The antiproliferative effect of type beta transforming growth factor occurs at a level distal from receptors for growth-activating factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
28 June 2018
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
28 June 2018
FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
1 reference
stated in
PubMed Central
reference URL
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retrieved
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Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231677
retrieved
21 September 2018
p70s6k function is essential for G1 progression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8943329
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8943329
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/8943329
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.16.12.6744
1 reference
stated in
Europe PubMed Central
PMCID
231677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
PMCID
231677
1 reference
stated in
Europe PubMed Central
PMCID
231677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
PubMed ID
8943329
1 reference
stated in
Europe PubMed Central
PMCID
231677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943329%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 October 2019
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