(Q33632331)

28 July 2017

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title

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site (English)

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28 July 2017

S G Sarafianos

1

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28 July 2017

K Das

2

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28 July 2017

J Ding

3

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28 July 2017

P L Boyer

4

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28 July 2017

S H Hughes

5

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28 July 2017

E Arnold

6

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28 July 2017

language of work or name

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1 May 1999

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28 July 2017

published in

Chemistry and Biology

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28 July 2017

volume

6

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28 July 2017

issue

5

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28 July 2017

page(s)

R137-46

1 reference

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

28 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

A minor groove binding track in reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structure of Taq polymerase with DNA at the polymerase active site

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Protein-nucleic acid interactions and DNA conformation in a complex of human immunodeficiency virus type 1 reverse transcriptase with a double-stranded DNA template-primer

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structure of DNA polymerase I Klenow fragment bound to duplex DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Significance of the O-helix residues of Escherichia coli DNA polymerase I in DNA synthesis: dynamics of the dNTP binding pocket

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Does the magnesium(II) ion interact with the alpha-phosphate of adenosine triphosphate? An investigation by oxygen-17 nuclear magnetic resonance

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

31P NMR of Mg-ATP in dilute solutions: complexation and exchange

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Function and structure relationships in DNA polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Site-specific mutagenesis of AIDS virus reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

The structure, catalytic mechanism and regulation of adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Closing in on HIV drug resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Molecular mechanisms of antiviral resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Kinetic mechanism of DNA polymerase I (Klenow).

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Conformational coupling in DNA polymerase fidelity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980071-4

7 January 2021

10.1016/S1074-5521(99)80071-4

Identifiers

DOI

1 reference

28 July 2017

1 reference