(Q33647242)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26259627%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial (English)

1 reference

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22 February 2020

1 reference

17

1 reference

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22 February 2020

J Vicente

2

1 reference

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22 February 2020

Ksenia Blinova

13

1 reference

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22 February 2020

author name string

L Johannesen

1

1 reference

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22 February 2020

J W Mason

3

1 reference

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22 February 2020

C Erato

4

1 reference

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22 February 2020

C Sanabria

5

1 reference

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22 February 2020

K Waite-Labott

6

1 reference

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22 February 2020

M Hong

7

1 reference

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22 February 2020

J Lin

8

1 reference

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22 February 2020

P Guo

9

1 reference

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22 February 2020

A Mutlib

10

1 reference

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22 February 2020

J Wang

11

1 reference

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22 February 2020

W J Crumb

12

1 reference

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22 February 2020

D Chan

14

1 reference

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22 February 2020

J Stohlman

15

1 reference

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22 February 2020

J Florian

16

1 reference

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22 February 2020

N Stockbridge

18

1 reference

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22 February 2020

D G Strauss

19

1 reference

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22 February 2020

language of work or name

English

0 references

publication date

28 November 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26259627%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacology & Therapeutics

22 February 2020

published in

1 reference

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22 February 2020

volume

99

1 reference

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22 February 2020

issue

2

1 reference

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22 February 2020

page(s)

214-223

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26259627%20AND%20SRC:MED&resulttype=core&format=json

Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil

22 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Dealing with global safety issues : was the response to QT-liability of non-cardiac drugs well coordinated?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Automatic extraction of ECG strips from continuous 12-lead holter recordings for QT analysis at prescheduled versus optimized time points.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

hERG potassium channels and cardiac arrhythmia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Drug-induced prolongation of the QT interval

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Pharmacological targeting of long QT mutant sodium channels

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Adrenergic modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.

28 July 2018

1 reference

Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.

21 January 2018

1 reference

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

21 January 2018

1 reference

Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.

21 January 2018

1 reference

Improving the assessment of heart toxicity for all new drugs through translational regulatory science.

21 January 2018

1 reference

Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre.

21 January 2018

1 reference

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

21 January 2018

1 reference

Relationship between an arrhythmogenic action of lidocaine and its effects on excitation patterns in acutely ischemic porcine myocardium

21 January 2018

1 reference

International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Actions of lidocaine on reentrant ventricular rhythms in the subacute myocardial infarction period in dogs.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Profibrillatory effects of lidocaine in the acutely ischemic porcine heart.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5421403

Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes

30 October 2018

1 reference

7 January 2021

A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

1 reference

7 January 2021

Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome

1 reference

7 January 2021

Reflex chronotropic and inotropic effects of calcium channel-blocking agents in conscious dogs. Diltiazem, verapamil, and nifedipine compared

1 reference

7 January 2021

Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man

1 reference

7 January 2021

Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias

1 reference

7 January 2021

Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans

1 reference

7 January 2021

Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine

1 reference

7 January 2021

Sex differences in the rate dependence of the T wave descending limb

1 reference

7 January 2021

Description of a nonselective cation current in human atrium

1 reference

7 January 2021

Identifiers

DOI

10.1002/CPT.205

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26259627%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26259627%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

26259627

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26259627%20AND%20SRC:MED&resulttype=core&format=json