(Q33651099)

28 July 2017

title

Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia (English)

1 reference

28 July 2017

1 reference

1 reference

Corentin Cras-Méneur

2

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author name string

Ernesto Bernal-Mizrachi

1

1 reference

28 July 2017

Bo Ra Ye

3

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28 July 2017

James D Johnson

4

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28 July 2017

M Alan Permutt

5

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28 July 2017

language of work or name

English

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publication date

3 August 2010

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28 July 2017

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28 July 2017

volume

5

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28 July 2017

issue

8

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28 July 2017

page(s)

e11969

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Creative Commons Attribution 4.0 International

28 July 2017

copyright license

start time

3 August 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2914754/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells

21 June 2018

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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

21 June 2018

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Glucose infusion in mice: a new model to induce beta-cell replication

21 June 2018

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Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

21 June 2018

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Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4.

21 June 2018

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Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

21 June 2018

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The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

21 June 2018

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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells

21 June 2018

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21 June 2018

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NFATc2-mediated repression of cyclin-dependent kinase 4 expression

21 June 2018

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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis

21 June 2018

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NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1.

21 June 2018

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Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

21 June 2018

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Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells

21 June 2018

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

21 June 2018

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Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.

21 June 2018

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Influence of tacrolimus on glucose metabolism before and after renal transplantation: a prospective study

21 June 2018

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Calcineurin: form and function

21 June 2018

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Calcineurin regulation of the mammalian G0/G1 checkpoint element, cyclin dependent kinase 4.

21 June 2018

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Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells

21 June 2018

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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediat

21 June 2018

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Neogenesis vs. apoptosis As main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats

21 June 2018

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 June 2018

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Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

21 June 2018

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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

21 June 2018

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Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel

21 June 2018

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Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Suppression of the expression of a pancreatic beta-cell form of the kinesin heavy chain by antisense oligonucleotides inhibits insulin secretion from primary cultures of mouse beta-cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells

21 June 2018

1 reference

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Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

21 June 2018

1 reference

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The mitogen-activated protein kinase pathway in rat islets of Langerhans: studies on the regulation of insulin secretion

21 June 2018

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Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures

21 June 2018

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Elevated intracellular calcium blocks programmed neuronal death

21 June 2018

1 reference

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Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Modulation of calcineurin phosphotyrosyl protein phosphatase activity by calmodulin and protease treatment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Type II diabetes, glucose "non-sense," and islet desensitization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914754

Specific and Combined Effects of Insulin and Glucose on Functional Pancreatic β-Cell Mass in Vivo in Adult Rats

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0011969

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0011969

Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0011969

Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0011969

Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity

21 January 2018

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12 December 2020

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

1 reference

12 December 2020

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12 December 2020

Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506

1 reference

12 December 2020

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0011969

Identifiers

DOI

1 reference

release_tubtbz2jtba2blvoaq3u3to3aq

28 July 2017

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1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tubtbz2jtba2blvoaq3u3to3aq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2914754

1 reference

28 July 2017

1 reference