(Q33656497)

28 July 2017

Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice (English)

1 reference

28 July 2017

1 reference

Naoto Koyama

7

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Gregory Stephanopoulos

10

object named as

Gregory Stephanopoulos

1 reference

28 July 2017

Yasushi Noguchi

1

1 reference

28 July 2017

Natsumi Nishikata

2

1 reference

28 July 2017

Nahoko Shikata

3

1 reference

28 July 2017

Yoshiko Kimura

4

1 reference

28 July 2017

Jose O Aleman

5

1 reference

28 July 2017

Jamey D Young

6

1 reference

28 July 2017

Joanne K Kelleher

8

1 reference

28 July 2017

Michio Takahashi

9

1 reference

28 July 2017

language of work or name

English

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publication date

10 August 2010

1 reference

28 July 2017

1 reference

28 July 2017

5

1 reference

28 July 2017

8

1 reference

28 July 2017

e12057

1 reference

Creative Commons Attribution 4.0 International

28 July 2017

start time

10 August 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Are high-protein, vegetable-based diets safe for kidney function? A review of the literature

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Hypothalamic mTOR signaling regulates food intake

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Treatment strategies in nonalcoholic fatty liver disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

High-protein weight-loss diets: are they safe and do they work? A review of the experimental and epidemiologic data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Evaluation of the use of amino acid composition data in assessing the protein quality of meat and poultry products

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

21 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Metabolic effects of orally administered amino acid mixture in elderly subjects with poorly controlled type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Characterization of dietary protein-dependent amino acid metabolism by linking free amino acids with transcriptional profiles through analysis of correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Amino acid-dependent modulation of glucose metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Quantitation and molecular species determination of diacylglycerols, phosphatidylcholines, ceramides, and sphingomyelins with gas chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012057

Network analysis of plasma and tissue amino acids and the generation of an amino index for potential diagnostic use.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

Food Intake Regulation: Amino Acid Toxicity and Changes in Rat Brain and Plasma Amino Acids

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919399

A Markedly Anti-lipotropic Action of Methionine

30 October 2018

1 reference

12 December 2020

34 Measurement of rates of lipogenesis with deuterated and tritiated water

1 reference

12 December 2020

The amino acid composition and the nutritive value of proteins. II. Amino acid mixtures as a dietary source of nitrogen for growth

1 reference

12 December 2020

Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms

1 reference

12 December 2020

The production of fatty livers in rats on threonine-and lysine-deficient diets

1 reference

12 December 2020

Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0012057

Identifiers

DOI

1 reference

28 July 2017

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28 July 2017

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