(Q33660709)

28 July 2017

1 reference

title

Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems (English)

1 reference

28 July 2017

1 reference

Toshiro Fujita

1

1 reference

28 July 2017

publication date

27 February 2014

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Journal of the American Society of Nephrology

28 July 2017

published in

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28 July 2017

volume

25

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28 July 2017

issue

6

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28 July 2017

page(s)

1148-1155

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Autoimmunity in the pathogenesis of hypertension

28 July 2017

cites work

1 reference

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14 July 2018

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The absence of intrarenal ACE protects against hypertension

14 July 2018

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Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation

14 July 2018

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14 July 2018

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Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

14 July 2018

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14 July 2018

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Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.

14 July 2018

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Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

14 July 2018

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Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation

14 July 2018

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14 July 2018

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WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway

14 July 2018

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14 July 2018

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The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

14 July 2018

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A SPAK isoform switch modulates renal salt transport and blood pressure

14 July 2018

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Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension

14 July 2018

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Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway

14 July 2018

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Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature

14 July 2018

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Renal nerves, WNK4, glucocorticoids, and salt transport

14 July 2018

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Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension

14 July 2018

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AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure

14 July 2018

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Cross-talk between aldosterone and angiotensin signaling in vascular smooth muscle cells

14 July 2018

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Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion

14 July 2018

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Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial

14 July 2018

1 reference

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Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Minireview: Aldosterone and mineralocorticoid receptors: past, present, and future

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure

14 July 2018

1 reference

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Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: results from a randomized trial

14 July 2018

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Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

14 July 2018

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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

14 July 2018

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Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

14 July 2018

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Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Glucocorticoid repression of human with-no-lysine (K) kinase-4 gene expression is mediated by the negative response elements in the promoter

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Mechanisms of sympathetic activation in obesity-related hypertension

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Physiology in perspective: The Wisdom of the Body. Neural control of the kidney

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Human adipocytes secrete mineralocorticoid-releasing factors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Altered renal handling of sodium in human hypertension: short review of the evidence

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Modulation of human mineralocorticoid receptor function by protein kinase A.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Heterogeneous responses to changes in dietary salt intake: the salt-sensitivity paradigm

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

alpha 1- and beta 2-adrenergic receptor expression in the Madin-Darby canine kidney epithelial cell line

14 July 2018

1 reference

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The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents

14 July 2018

1 reference

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The surprising kidney-fluid mechanism for pressure control--its infinite gain!

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Abnormal pressure natriuresis. A cause or a consequence of hypertension?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

A micropuncture study of the effect of isoprenaline on renal tubular fluid and electrolyte transport in the rat

14 July 2018

1 reference

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Impressive blood pressure and heart rate response after percutaneous renal denervation in a woman with morbid obesity and severe drug-resistant hypertension.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway

30 October 2018

1 reference

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Efficacy of spironolactone therapy in patients with true resistant hypertension.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

-2 Adrenergic Receptor Diplotype Defines a Subset of Salt-Sensitive Hypertension

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Role of renal nerves in development of hypertension in DOCA-salt model in rats: a telemetric approach

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Efficacy of low-dose spironolactone in subjects with resistant hypertension

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Localization of thiazide-sensitive Na(+)-Cl(-) cotransport and associated gene products in mouse DCT.

30 October 2018

1 reference

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Abnormal relationship between sodium intake and sympathetic nervous system activity in salt-sensitive patients with essential hypertension.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033384

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

30 October 2018

1 reference

12 December 2020

Successful preoperative treatment of a patient with resistant hypertension who had percutaneous renal denervation therapy before bariatric surgery

1 reference

12 December 2020

High potassium intake attenuates antinatriuretic response to air stress in DOCA-salt rats

1 reference

12 December 2020

Factors influencing blood pressure in salt-sensitive patients with hypertension

1 reference

12 December 2020

L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes

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12 December 2020

Proximal Sodium Reabsorption

1 reference

12 December 2020

Hemodynamic and endocrine changes associated with potassium supplementation in sodium-loaded hypertensives

1 reference

12 December 2020

Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors

1 reference

12 December 2020

The Arg16Gly polymorphism of the beta2-adrenergic receptor and the natriuretic response to rapid saline infusion in humans

1 reference

12 December 2020

T regulatory lymphocytes prevent aldosterone-induced vascular injury

1 reference

12 December 2020

Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress

1 reference

12 December 2020

Plasma and urinary catecholamines in salt-sensitive idiopathic hypertension

1 reference

12 December 2020

Identifiers

DOI

10.1681/ASN.2013121258

1 reference

28 July 2017

1 reference

28 July 2017

1 reference