(Q38690025)

5 September 2017

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension (English)

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5 September 2017

arterial hypertension

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author

David H. Ellison

12

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5 September 2017

7

Alexander Paliege

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author name string

Ewout J Hoorn

1

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5 September 2017

Stephen B Walsh

2

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5 September 2017

James A McCormick

3

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5 September 2017

Antje Fürstenberg

4

1 reference

5 September 2017

Chao-Ling Yang

5

1 reference

5 September 2017

Tom Roeschel

6

1 reference

5 September 2017

Alexander Paliege

7

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5 September 2017

Alexander J Howie

8

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5 September 2017

James Conley

9

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5 September 2017

Sebastian Bachmann

10

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5 September 2017

Robert J Unwin

11

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5 September 2017

language of work or name

English

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publication date

2 October 2011

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5 September 2017

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5 September 2017

17

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5 September 2017

10

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5 September 2017

1304-1309

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describes a project that uses

5 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3192268/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Role of the WNK-activated SPAK kinase in regulating blood pressure

6 September 2017

1 reference

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Genetic analysis of blood pressure in 8 mouse intercross populations

6 September 2017

1 reference

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Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

FKBP family proteins: immunophilins with versatile biological functions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

6 September 2017

1 reference

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WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells

6 September 2017

1 reference

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Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome

6 September 2017

1 reference

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WNK kinases regulate thiazide-sensitive Na-Cl cotransport

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

6 September 2017

1 reference

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Hypertensinogenic mechanism of the calcineurin inhibitors

6 September 2017

1 reference

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Mechanisms and consequences of arterial hypertension after renal transplantation

6 September 2017

1 reference

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Control of vascular tone in the syndromes of Bartter and Gitelman

6 September 2017

1 reference

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Blood pressure control--special role of the kidneys and body fluids

6 September 2017

1 reference

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Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta

6 September 2017

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Abnormalities of Gq-mediated cell signaling in Bartter and Gitelman syndromes

23 June 2018

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Mechanisms of FK 506-induced hypertension in the rat.

23 June 2018

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Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent

23 June 2018

1 reference

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Posttransplantation hypomagnesemia and its relation with immunosuppression as predictors of new-onset diabetes after transplantation.

23 June 2018

1 reference

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The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Validation of volume-pressure recording tail-cuff blood pressure measurements

31 August 2018

1 reference

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Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat.

31 August 2018

1 reference

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Primary immunosuppression with tacrolimus in kidney transplantation: three-year follow-up in a single center

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Aldosterone resistance in kidney transplantation is in part induced by a down-regulation of mineralocorticoid receptor expression

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Hyponatraemia and hyperkalaemia are more frequent in renal transplant recipients treated with tacrolimus than with cyclosporin. Further evidence for differences between cyclosporin and tacrolimus nephrotoxicities

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

On the natriuretic effect of verapamil: inhibition of ENaC and transepithelial sodium transport

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

What have we learned about primary liver transplantation under tacrolimus immunosuppression? Long-term follow-up of the first 1000 patients.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192268

HYPERTENSION AND HYPERPOTASSAEMIA WITHOUT RENAL DISEASE IN A YOUNG MALE

31 August 2018

1 reference

12 December 2020

Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American H

1 reference

12 December 2020

A thiazide test for the diagnosis of renal tubular hypokalemic disorders

1 reference

12 December 2020

Ciclosporin-induced hypertension is associated with increased sodium transporter of the loop of Henle (NKCC2)

1 reference

12 December 2020

Hypertension and allograft nephropathy--cause, consequence, or both?

1 reference

12 December 2020

Interaction of cyclosporine and FK506 with diuretics in transplant patients

1 reference

12 December 2020

Reduced content of alpha subunit of Gq protein content in monocytes of Bartter and Gitelman syndromes: relationship with vascular hyporeactivity

1 reference

12 December 2020

Cyclosporine metabolic side effects: association with the WNK4 system

1 reference

12 December 2020

Hyperkalaemia in cyclosporin-treated renal allograft recipients

1 reference

12 December 2020

Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.2497

1 reference

5 September 2017

1 reference

5 September 2017

PubMed publication ID

21963515

1 reference