(Q33667168)

English

Mechanism of Potentiation of a Dysfunctional Epilepsy-Linked Mutated GABAA Receptor by a Neurosteroid (3α, 21-Dihydroxy-5α-pregnan-20-one): Transient Kinetic Investigations

scientific article published on September 14, 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Mechanism of potentiation of a dysfunctional epilepsy-linked mutated GABA(A) receptor by a neurosteroid (3alpha, 21-dihydroxy-5alpha-pregnan-20-one): transient kinetic investigations (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Mechanism of Potentiation of a Dysfunctional Epilepsy-Linked Mutated GABAA Receptor by a Neurosteroid (3α, 21-Dihydroxy-5α-pregnan-20-one): Transient Kinetic Investigations (English)

1 reference

10.1021/BI901241G

https://api.crossref.org/works/10.1021/BI901241G

20 June 2024

author name string

Latha Ramakrishnan

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

George P. Hess

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20726514

20 June 2024

language of work or name

0 references

publication date

1 September 2010

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

14 September 2010

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20726514

20 June 2024

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/bi901241g

1 reference

10.1021/BI901241G

https://api.crossref.org/works/10.1021/BI901241G

20 June 2024

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

49

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Europe PubMed Central

PubMed publication ID

28 July 2017

36

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

7892-7901

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy

5

1 reference

10.1021/BI901241G

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GABA(A) receptor epilepsy mutations

6

1 reference

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GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies

7

1 reference

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The juvenile myoclonic epilepsy GABA(A) receptor alpha1 subunit mutation A322D produces asymmetrical, subunit position-dependent reduction of heterozygous receptor currents and alpha1 subunit protein expression

8

1 reference

10.1021/BI901241G

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Molecular analysis of the A322D mutation in the GABA receptor alpha-subunit causing juvenile myoclonic epilepsy

9

1 reference

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A novel GABRG2 mutation associated with febrile seizures

10

1 reference

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On the mechanism of a mutated and abnormally functioning gamma-aminobutyric acid (A) receptor linked to epilepsy

11

1 reference

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The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum.

12

1 reference

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A GABAA receptor mutation linked to human epilepsy (gamma2R43Q) impairs cell surface expression of alphabetagamma receptors

13

1 reference

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Development and application of caged ligands for neurotransmitter receptors in transient kinetic and neuronal circuit mapping studies

14

1 reference

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Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors

15

1 reference

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Synthesis, photochemistry, and biological characterization of photolabile protecting groups for carboxylic acids and neurotransmitters

16

1 reference

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20 June 2024

On the mechanism of alleviation by phenobarbital of the malfunction of an epilepsy-linked GABA(A) receptor

17

1 reference

10.1021/BI901241G

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20 June 2024

Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states

18

1 reference

10.1021/BI901241G

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20 June 2024

Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

19

1 reference

10.1021/BI901241G

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20 June 2024

The clinical potentials of endogenous neurosteroids.

20

1 reference

10.1021/BI901241G

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20 June 2024

Journal of Pharmacology and Experimental Therapeutics

21

280

1284

author name string

Carter R. B.

publication date

1997

1 reference

10.1021/BI901241G

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20 June 2024

Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice

22

1 reference

10.1021/BI901241G

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20 June 2024

Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice

23

1 reference

10.1021/BI901241G

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20 June 2024

Ciba Foundation Symposium

25

153

83

author name string

Majewska M. D.

1 reference

10.1021/BI901241G

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20 June 2024

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

26

1 reference

10.1021/BI901241G

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Functional properties of recombinant rat GABAA receptors depend upon subunit composition

27

1 reference

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Green fluorescent protein as a marker for gene expression

28

1 reference

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Chemical kinetic measurements of a mammalian acetylcholine receptor by a fast-reaction technique

29

1 reference

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

30

1 reference

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Electrophysiological characterization of GABAA receptors in anterior pituitary cells of newborn rats.

31

1 reference

10.1021/BI901241G

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20 June 2024

Rapid photolytic release of adenosine 5'-triphosphate from a protected analog: utilization by the sodium:potassium pump of human red blood cell ghosts

32

1 reference

10.1021/BI901241G

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20 June 2024

How fast does the gamma-aminobutyric acid receptor channel open? Kinetic investigations in the microsecond time region using a laser-pulse photolysis technique

34

1 reference

10.1021/BI901241G

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20 June 2024

gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus

35

1 reference

10.1021/BI901241G

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20 June 2024

Journal of Pharmacology and Experimental Therapeutics

36

270

1223

author name string

Kokate T. G.

publication date

1994

1 reference

10.1021/BI901241G

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20 June 2024

How fast does an acetylcholine receptor channel open? Laser-pulse photolysis of an inactive precursor of carbamoylcholine in the microsecond time region with BC3H1 cells

37

1 reference

10.1021/BI901241G

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Neurosteroids act on recombinant human GABAA receptors

38

1 reference

10.1021/BI901241G

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Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.

39

1 reference

10.1021/BI901241G

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20 June 2024

Effect of steroids on ?-aminobutyrate-induced currents in cultured rat astrocytes

40

1 reference

10.1021/BI901241G

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20 June 2024

Molecular Pharmacology

41

41

89

author name string

Woodward R. M.

publication date

1992

1 reference

10.1021/BI901241G

https://api.crossref.org/works/10.1021/BI901241G

20 June 2024

Multiple modulatory effects of the neuroactive steroid pregnanolone on GABAA receptor in frog pituitary melanotrophs.

42

1 reference

10.1021/BI901241G

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In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.

43

1 reference

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Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.

44

1 reference

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Mechanism-based discovery of small molecules that prevent noncompetitive inhibition by cocaine and MK-801 mediated by two different sites on the nicotinic acetylcholine receptor

45

1 reference

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Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.

46

1 reference

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Neuroactive steroids have multiple actions to potentiate GABAA receptors

47

1 reference

10.1021/BI901241G

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Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors.

49

1 reference

10.1021/BI901241G

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20 June 2024

Picrotoxin inhibition mechanism of a gamma-aminobutyric acid A receptor investigated by a laser-pulse photolysis technique

50

1 reference

10.1021/BI901241G

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20 June 2024

The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor

51

1 reference

10.1021/BI901241G

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20 June 2024

Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors

52

1 reference

10.1021/BI901241G

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20 June 2024

An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits

53

1 reference

10.1021/BI901241G

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20 June 2024

Identifiers

10.1021/BI901241G

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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