(Q42683643)

English

An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits

scientific article published on 20 April 2006

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scholarly article

1 reference

Europe PubMed Central

4 November 2017

An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits (English)

1 reference

Europe PubMed Central

4 November 2017

author name string

Tim G Hales

1

1 reference

Europe PubMed Central

4 November 2017

Tarek Z Deeb

2

1 reference

Europe PubMed Central

4 November 2017

Haiyan Tang

3

1 reference

Europe PubMed Central

4 November 2017

Karen A Bollan

4

1 reference

Europe PubMed Central

4 November 2017

Dale P King

5

1 reference

Europe PubMed Central

4 November 2017

Sara J Johnson

6

1 reference

Europe PubMed Central

4 November 2017

Christopher N Connolly

7

1 reference

Europe PubMed Central

4 November 2017

language of work or name

0 references

publication date

20 April 2006

1 reference

Europe PubMed Central

4 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

4 November 2017

281

1 reference

Europe PubMed Central

4 November 2017

25

1 reference

Europe PubMed Central

4 November 2017

17034-17043

1 reference

Europe PubMed Central

4 November 2017

A novel class of ligand-gated ion channel is activated by Zn2+

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The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function.

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Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues.

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Kindling and status epilepticus models of epilepsy: rewiring the brain

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First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene

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Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures

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Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy

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Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus

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21 January 2018

Childhood absence epilepsy and febrile seizures: a family with a GABA(A) receptor mutation

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21 January 2018

GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies

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A mutation in the GABAA receptor alpha 1 subunit linked to human epilepsy affects channel gating properties

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The juvenile myoclonic epilepsy GABA(A) receptor alpha1 subunit mutation A322D produces asymmetrical, subunit position-dependent reduction of heterozygous receptor currents and alpha1 subunit protein expression

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Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

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21 January 2018

A GABAA receptor mutation linked to human epilepsy (gamma2R43Q) impairs cell surface expression of alphabetagamma receptors

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21 January 2018

The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum.

1 reference

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21 January 2018

The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors

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21 January 2018

Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies.

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Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis

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21 January 2018

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

1 reference

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21 January 2018

Charged amino acids of the N-terminal domain are involved in coupling binding and gating in alpha7 nicotinic receptors

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21 January 2018

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

1 reference

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21 January 2018

Coupling of agonist binding to channel gating in the GABA(A) receptor

1 reference

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21 January 2018

Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation

1 reference

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21 January 2018

Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.

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21 January 2018

Asymmetric contribution of alpha and beta subunits to the activation of alphabeta heteromeric glycine receptors

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21 January 2018

Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

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21 January 2018

On the mechanism of a mutated and abnormally functioning gamma-aminobutyric acid (A) receptor linked to epilepsy

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21 January 2018

Structure and gating mechanism of the acetylcholine receptor pore

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21 January 2018

Homology model of the GABAA receptor examined using Brownian dynamics

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21 January 2018

Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors.

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21 January 2018

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

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21 January 2018

Potentiation, activation and blockade of GABAA receptors of clonal murine hypothalamic GT1-7 neurones by propofol.

1 reference

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21 January 2018

Evidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptors

1 reference

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21 January 2018

Data transformations for improved display and fitting of single-channel dwell time histograms

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The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

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Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells.

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Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

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21 January 2018

Role of the conserved lysine residue in the middle of the predicted extracellular loop between M2 and M3 in the GABA(A) receptor

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21 January 2018

Febrile seizures: an update

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21 January 2018

Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital

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Neuroactive steroids have multiple actions to potentiate GABAA receptors

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Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

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GABA(A) receptor composition is determined by distinct assembly signals within alpha and beta subunits

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21 January 2018

Identifiers

10.1074/JBC.M603599200

1 reference

Europe PubMed Central

4 November 2017

1 reference

Europe PubMed Central

4 November 2017

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