(Q33668993)

28 July 2017

title

From natural to synthetic multisite thrombin inhibitors (English)

1 reference

ORCID Public Data File 2021

28 July 2017

1 reference

author name string

Lombardi A

1

1 reference

28 July 2017

De Simone G

2

1 reference

28 July 2017

Galdiero S

3

1 reference

28 July 2017

Staiano N

4

1 reference

28 July 2017

Nastri F

5

1 reference

28 July 2017

Pavone V

6

1 reference

28 July 2017

language of work or name

1 reference

1 January 1999

1 reference

28 July 2017

number of pages

21

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based on heuristic

inferred from page(s)

published in

Biopolymers

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28 July 2017

volume

51

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28 July 2017

issue

1

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28 July 2017

page(s)

19-39

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Strategies for the design of novel thrombolytic and antithrombolytic agents

28 July 2017

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1 reference

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Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution

21 January 2018

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Biological implications of a 3 A structure of dimeric antithrombin

21 January 2018

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The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

21 January 2018

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The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

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The anticoagulant activation of antithrombin by heparin

21 January 2018

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Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A

21 January 2018

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Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin

21 January 2018

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The structure of a complex of recombinant hirudin and human alpha-thrombin

21 January 2018

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Refined structure of the hirudin-thrombin complex

21 January 2018

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Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug

21 January 2018

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Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin

21 January 2018

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Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.

21 January 2018

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

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A player of many parts: the spotlight falls on thrombin's structure.

21 January 2018

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On the size of the active site in proteases. I. Papain

21 January 2018

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The crystal structure of α-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode

21 January 2018

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Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study

21 January 2018

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Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex

21 January 2018

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21 January 2018

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Energetics of thrombin-fibrinogen interaction.

21 January 2018

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Domains specifying thrombin–receptor interaction

21 January 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

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Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes

21 January 2018

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Protease-activated receptor 3 is a second thrombin receptor in humans

21 January 2018

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Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin

21 January 2018

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Molecular mapping of the heparin-binding exosite of thrombin

21 January 2018

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The interaction of thrombin with fibrinogen. A structural basis for its specificity

21 January 2018

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Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues

21 January 2018

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Discovering protein secondary structures: Classification and description of isolated α-turns

21 January 2018

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Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

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Antithrombin in vertebrate species: conservation of the heparin-dependent anticoagulant mechanism

21 January 2018

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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

21 January 2018

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Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects

21 January 2018

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The development of hirudin as an antithrombotic drug

21 January 2018

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Kinetics of the inhibition of thrombin by hirudin.

21 January 2018

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Development of hirudin as an antithrombotic agent

21 January 2018

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Conformation of recombinant desulfatohirudin in aqueous solution determined by nuclear magnetic resonance

21 January 2018

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Nuclear magnetic resonance solution structure of hirudin(1-51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain

21 January 2018

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Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin

21 January 2018

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Primary structures of new 'iso-hirudins'.

21 January 2018

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Primary structure and function of novel O-glycosylated hirudins from the leech Hirudinaria manillensis

21 January 2018

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The C-terminal binding domain of hirullin P18. Antithrombin activity and comparison to hirudin peptides

21 January 2018

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Triabin, a highly potent exosite inhibitor of thrombin

21 January 2018

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Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 Å resolution

21 January 2018

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Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

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Protein inhibitors of proteinases

21 January 2018

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Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

21 January 2018

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A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond

21 January 2018

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Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors

21 January 2018

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Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6

21 January 2018

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Hirulog peptides with scissile bond replacements resistant to thrombin cleavage.

21 January 2018

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Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors

21 January 2018

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Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin

21 January 2018

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Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin

21 January 2018

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Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic

21 January 2018

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Protein Data Bank archives of three-dimensional macromolecular structures.

21 January 2018

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Proton nuclear magnetic resonance study of hirudin: resonance assignment and secondary structure

21 January 2018

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Late-fibrin(ogen) fragment E modulates human alpha-thrombin specificity

21 January 2018

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Structure of N-terminal Fragments of Fibrinogen and Specificity of Thrombin

21 January 2018

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10.1002/(SICI)1097-0282(1999)51:1<19::AID-BIP4>3.0.CO;2-G

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference