(Q42845204)

English

Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic

scientific article published on March 1996

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic (English)

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

author name string

R Krishnan

1

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

A Tulinsky

2

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

G P Vlasuk

3

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

D Pearson

4

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

P Vallar

5

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

P Bergum

6

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

T K Brunck

7

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

W C Ripka

8

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

publication date

1 March 1996

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

Protein Science

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

5

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

3

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

422-433

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

Active site and exosite binding of alpha-thrombin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Structure-function relationships of the thrombin-thrombomodulin interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Thrombin specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Structure of a tetrahedral transition state complex of alpha-chymotrypsin dimer at 1.8-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Development of hirudin as an antithrombotic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

The roles of protein C and thrombomodulin in the regulation of blood coagulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Domains specifying thrombin–receptor interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

The interaction of thrombin with fibrinogen. A structural basis for its specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Conformationally restricted thrombin inhibitors resistant to proteolytic digestion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

17 The kinetics of reversible tight-binding inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Hirulog peptides with scissile bond replacements resistant to thrombin cleavage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2143369

27 May 2018

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid sequence of the heavy chain of bovine protein C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereochemically restrained refinement of macromolecular structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bifunctional thrombin inhibitors based on the sequence of hirudin45-65

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of thrombin and other trypsin-like serine proteinases by cyclotheonamide A

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin, thrombin inhibitors, and the arterial thrombotic process

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of thrombin receptor expression during vascular lesion formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8868478

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PRO.5560050303

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 November 2017

ResearchGate publication ID

0 references

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