(Q33691162)

28 July 2017

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title

Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation (English)

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28 July 2017

1 reference

Hatse S

1

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28 July 2017

De Clercq E

series ordinal

2

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28 July 2017

Balzarini J

series ordinal

3

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28 July 2017

language of work or name

English

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publication date

1 August 1999

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28 July 2017

Biochemical Pharmacology

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28 July 2017

58

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28 July 2017

539-555

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28 July 2017

4

1 reference

Comparative Investigation of the Free Nucleotides of an Ascitic Hepatoma and of Normal or Regenerating Liver

28 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Activity of cytidine triphosphate synthetase in normal and neoplastic tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Thymidylate synthase inhibition: a structure-based rationale for drug design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

A qualitative and quantitative cytochemical assay of dihydrofolate reductase in erythroid cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Increased thymidylate synthase gene expression in metastatic melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

IMP dehydrogenase, an enzyme linked with proliferation and malignancy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Regulation and role of inosine-5'-monophosphate dehydrogenase in cell replication, malignant transformation, and differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

DNA polymerase and thymidine kinase activities in MC-29 virus-induced transplantable hepatoma and the effect of cytostatic treatment of these activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Role of ribonucleotide reductase in expression in the neoplastic program.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

S-Phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Identification of genes expressed in premalignant breast disease by microscopy-directed cloning

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Imbalance in the ribonucleotide pools of lymphoid cells from acute lymphoblastic leukemia patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

DNA methylation properties: consequences for pharmacology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Cellular differentiation, cytidine analogs and DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

A biochemical function for ras--at last

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Phorbol ester-induced differentiation of chronic lymphocytic leukaemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Genistein as an inducer of tumor cell differentiation: possible mechanisms of action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Polar/apolar compounds induce leukemia cell differentiation by modulating cell-surface potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of erythroid differentiation in the human leukaemia cell line K562.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Differentiation antigens of melanocytes and melanoma: analysis of melanosome and cell surface markers of human pigmented cells with monoclonal antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of teratocarcinoma cell differentiation. Effect of the inhibitors of DNA synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Growth inhibition and induction of phenotypic alterations in MCF-7 breast cancer cells by an IMP dehydrogenase inhibitor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

A new three-dimensional culture of human keratinocytes: optimization of differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Regression and differentiation of neuroblastoma tumors in mice treated with differentiating agents--prostaglandin E1 and a phosphodiesterase inhibitor, RO 20-1724

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Establishment and characterization of a continuous in vitro line from a rat choriocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Inhibition of CTP synthetase induces differentiation of HL-60 cells and down-regulation of the c-myc oncogene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

3-Deazauridine (NSC 126849): an interesting modulator of biochemical response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Enhancement of the antileukemic activity of 5-aza-2'-deoxycytidine by cyclopentenyl cytosine in HL-60 leukemic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of erythroid differentiation by 5-fluorouracil in K562 leukemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Keratinocytes differentiate in response to inhibitors of deoxyribonucleotide synthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Effect of fluorodeoxyuridine on neurons and non-neuronal cells in cerebral explants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The effect of induction of hemoglobin synthesis in cultured Friend cells on the number of initiation sites for replication and transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Methotrexate induces differentiation of human keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Retinoic acid and methotrexate specifically increase PHA-E-lectin binding to a 67-kDa glycoprotein in LA-N-1 human neuroblastoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Design of enzyme inhibitors using iterative protein crystallographic analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Effects of differentiation-inducing agents on purine nucleotide metabolism in an ovarian cancer cell line.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Nucleoside Analogues as Chemotherapeutic Agents: A Review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The purine path to chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Differentiation of neuroblastoma cells induced in culture by 6-thioguanine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of erythroid differentiation in vitro by purines and purine analogues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of cell differentiation by IMPDH antisense oligomer in HL-60 and K562 human leukemia cell lines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Role of differentiation induction in action of purine antimetabolites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Differential regulation of choriocarcinoma gene expression by DNA synthesis inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Effects of hydroxyurea and cyclic adenosine monophosphate/protein kinase A inhibitors on the expression of the human chorionic gonadotropin alpha subunit and c-myc genes in choriocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Involvement of ribonucleotide reductase in cellular differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Resistance of the human colon carcinoma cell line HCT-8 to methotrexate results in selection of cells with features of enterocytic differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Inhibition of DNA polymerase-α and -β of calf thymus by 1-β-d-arabinofuranosylcytosine-5′-triphosphate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Enhanced release of nascent single strands from DNA synthesized in the presence of arabinosylcytosine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Gamma-interferon, retinoic acid, and cytosine arabinoside induce neuroblastoma differentiation by different mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Variable DNA methylation changes during differentiation of human melanoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Effects of maturational agents on expression and secretion of two partially characterized high molecular weight milk-related glycoproteins in MCF-7 breast carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Inhibition of DNA synthesis causes stem cell differentiation: induction of teratocarcinoma F9 cell differentiation with nucleoside analogues of DNA-synthesis inhibitors and their inducing abilities counterbalanced specifically by normal nucleosides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Terminal differentiation of human erythroleukemia cell line K562 induced by aphidicolin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Aphidicolin induces myogenic differentiation in the human rhabdomyosarcoma cell line KFR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

A novel selective broad-spectrum anti-DNA virus agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter: evidence for the role of Sp1 and not of c-Myb or PU.1 in myelomonocytic lineage-specific expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Induction of erythroid differentiation in leukaemic K562 cells by an S-adenosylhomocysteine hydrolase inhibitor, aristeromycin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Reversal of enzymic phenotype of thymidine metabolism in induced differentiation of HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Identification of cellular differentiation-dependent nuclear factors that bind to a human gene for thymidylate synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Thymidine Salvage Changes with Differentiation in Human Keratinocytes In Vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Purine metabolism in myeloid precursor cells during maturation. Studies with the HL-60 cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Relationship between transient DNA hypomethylation and erythroid differentiation of murine erythroleukemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

S-adenosylhomocysteine hydrolase activity during differentiation of HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

c-myc and c-fos expression in differentiating mouse primary keratinocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

In K562 leukemia cells treated with doxorubicin and hemin, a decrease in c-myc mRNA expression correlates with loss of self-renewal capability but not with erythroid differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Changing expression of GTPase activating proteins with differentiation in neuroblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2899%2900035-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(99)00035-0

1 reference

28 July 2017

1 reference