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Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment
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scholarly article
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stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
main subject
toxicity
0 references
author name string
Lake BG
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
language of work or name
English
1 reference
based on heuristic
inferred from title
publication date
1 April 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
published in
Food and Chemical Toxicology
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
volume
37
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
page(s)
423-453
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
cites work
DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of effect of coumarin on unscheduled DNA synthesis in precision-cut human liver slices
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative in vitro skin absorption and metabolism of coumarin (1,2-benzopyrone) in human, rat, and mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interspecies differences in coumarin metabolism in liver microsomes examined by capillary electrophoresis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective Clara cell injury in mouse lung following acute administration of coumarin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and CD-1 mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Frequency of coumarin hepatotoxicity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strain-specific enhancement or inhibition of coumarin hepatotoxicity in mice following pretreatment with two different liver enzyme-inducing agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and alternative splicing of the cytochrome P-450 CYP2A7
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of Mongolian gerbil and rat hepatic microsomal monooxygenase activities: high coumarin 7-hydroxylase activity in the gerbil
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of coumarin 7-hydroxylase activity in human liver microsomes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatography
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coumarin toxicity in different strains of mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the induction of cholangiofibrosis by coumarin in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two-year toxicity study on coumarin in the baboon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxic hepatitis due to benzo-pyrone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the effects of inducers of cytochrome P450 on Mongolian gerbil and rat hepatic microsomal monooxygenase activities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of coumarin by rat, gerbil and human liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
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based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
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inferred from DOI database lookup
Species differences in the hepatotoxicity of coumarin: a comparison of rat and Mongolian gerbil
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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inferred from DOI database lookup
O-hydroxyphenylacetaldehyde: a major novel metabolite of coumarin formed by rat, gerbil and human liver microsomes
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
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inferred from DOI database lookup
Toxicity of coumarin and various methyl derivatives in cultures of rat hepatocytes and V79 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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inferred from DOI database lookup
Comparison of in vivo and in vitro rat hepatic toxicity of coumarin and methyl analogues, and application of quantitative morphometry to toxicity in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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inferred from DOI database lookup
3-Hydroxylation of coumarin or 4-methylcoumarin by rat-liver microsomes and its induction by 4-methylcoumarin given orally
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3 The Metabolism and Biological Actions of Coumarins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Liver response tests. VII. Coumarin metabolism in relation to the inhibition of rat-liver glucose 6-phosphatase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of 7,12-dimethylbenz(alpha) anthracene-induced breast carcinoma by coumarin in the rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
[Pathological-anatomical results on the effect of coumarin in animal experiments (author's transl)]
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic effects of coumarins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Carcinogenicity results for 114 laboratory animal studies used to assess the predictivity of four in vitro genetic toxicity assays for rodent carcinogenicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of chemical carcinogens by assay of unscheduled DNA synthesis in rat tracheal epithelium in short-term organ culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coumarin-7-hydroxylase activity in microsomes from needle biopsies of normal and diseased human liver
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of precision-cut liver slices to evaluate species differences in 2-acetylaminofluorene-induced unscheduled DNA synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the acute effects of coumarin and some coumarin derivatives in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the hepatotoxicity of coumarin in the rat, mouse, and Syrian hamster: a dose and time response study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of o-hydroxyphenylacetaldehyde as a major metabolite of coumarin in rat hepatic microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of coumarin by precision-cut calf liver slices and calf liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the metabolism and disposition of [3-14C]coumarin in the rat and marmoset (Callithrix jacchus)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
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Molecular modelling of members of the P4502A subfamily: application to studies of enzyme specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coumarin-induced hepatotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antitumour activity of coumarin and 7-hydroxycoumarin against 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies in detoxication. 72. The metabolism of coumarin and of o-coumaric acid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies in detoxication. 71. The metabolism of hydroxycoumarins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of coumarin and its urinary metabolites by high-performance liquid chromatography
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coumarin inhibits micronuclei formation induced by benzo(a)pyrene in male but not female ICR mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tolerance to multiple doses of the pulmonary toxicant, naphthalene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enzyme induction in the cytochrome P-450 system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Monographs on fragrance raw materials
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatitis A impairs the function of human hepatic CYP2A6 in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue and sex-dependent differences in CYP2A activities in hamsters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of inducers of cytochrome P-450 on the metabolism of [3-14C]coumarin by rat hepatic microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
(3-14C) coumarin distribution in rat tissues after the injection of a single dose
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ultrastructure of the Nonciliated Bronchiolar Epithelial (Clara) Cell of Mammalian Lung. III. A Study of Man with Comparison of 15 Mammalian Species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ultrastructure of the Nonciliated Bronchiolar Epithelial (Clara) Cell of Mammalian Lung: I. A Comparison of Rabbit, Guinea Pig, Rat, Hamster, and Mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the toxicity of allyl alcohol, coumarin and menadione in precision-cut rat, guinea-pig, cynomolgus monkey and human liver slices
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pilot Study on Bioavailability of Coumarin and 7‐Hydroxycoumarin upon Peroral Administration of Coumarin in a Sustained‐Release Dosage Form
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppressing effect of antimutagenic flavorings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the role of the intestinal microflora in the metabolism of coumarin in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of coumarin in man.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NATURALLY OCCURRING COUMARINS AND RELATED PHYSIOLOGICAL ACTIVITIES.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-carcinogenic response to coumarin in Syrian golden hamsters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemical mutagenesis testing in Drosophila. VI. Interlaboratory comparison of mutagenicity tests after treatment of larvae.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism of [3-14C] coumarin by human liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The metabolism of (2- 14 C) coumarin and (2- 14 C)-7-hydroxycoumarin in the rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The metabolic fate of [14C]coumarin in baboons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High-performance liquid chromatography of coumarin and its metabolites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Does the Delaney Clause of the U.S. Food and Drug laws prevent human cancers?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human hepatic cytochromes P450 involved in drug metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of lung injury by systemically administered chemicals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Percutaneous absorption and metabolism of Coumarin in human and rat skin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0278-6915(99)00010-1
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
PubMed ID
10418958
1 reference
stated in
Europe PubMed Central
PubMed ID
10418958
retrieved
28 July 2017
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