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The development and therapeutic potential of protein kinase inhibitors
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
The development and therapeutic potential of protein kinase inhibitors
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
author name string
Cohen P
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
publication date
1 August 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
published in
Current Opinion in Chemical Biology
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stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
volume
3
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
page(s)
459-465
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stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
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Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors
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In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
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Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans.
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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
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Identification of a novel inhibitor of mitogen-activated protein kinase kinase
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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
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Mechanism of activation and function of protein kinase B.
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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
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The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle
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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
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Transformation mediated by RhoA requires activity of ROCK kinases
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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.
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Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration
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Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading
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Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
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The search for physiological substrates of MAP and SAP kinases in mammalian cells
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TOR signalling and control of cell growth
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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
1 reference
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7 January 2021
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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
1 reference
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7 January 2021
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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2899%2980067-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059
1 reference
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Crossref
reference URL
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7 January 2021
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Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
1 reference
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Crossref
reference URL
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The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2899%2980067-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2899%2980067-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1367-5931%2899%2980067-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1367-5931(99)80067-2
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
PubMed ID
10419844
1 reference
stated in
Europe PubMed Central
PubMed ID
10419844
retrieved
28 July 2017
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