(Q33703478)

28 July 2017

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title

Insulin signalling: metabolic pathways and mechanisms for specificity (English)

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28 July 2017

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Nystrom FH

1

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28 July 2017

Quon MJ

series ordinal

2

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28 July 2017

language of work or name

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1 August 1999

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28 July 2017

number of pages

12

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inferred from page(s)

published in

Cellular Signalling

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28 July 2017

volume

11

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28 July 2017

issue

8

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28 July 2017

page(s)

563-574

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

28 July 2017

cites work

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Novel mechanisms of RTK signal generation

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7 January 2021

Dimerization of cell surface receptors in signal transduction

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7 January 2021

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7 January 2021

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7 January 2021

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Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy.

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7 January 2021

Molecular determinants of insulin action

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7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

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7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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7 January 2021

SH2 domains recognize specific phosphopeptide sequences

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7 January 2021

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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7 January 2021

Signal transduction by the PDGF receptors

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7 January 2021

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

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7 January 2021

Insulin signal transduction and the IRS proteins

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7 January 2021

Role of IRS-2 in insulin and cytokine signalling

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7 January 2021

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

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7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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7 January 2021

Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling

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7 January 2021

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

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7 January 2021

Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2

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7 January 2021

Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor

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7 January 2021

The IRS-signalling system: a network of docking proteins that mediate insulin action

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7 January 2021

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

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7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

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7 January 2021

Insulin signal transduction pathways

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

PDK1, one of the missing links in insulin signal transduction?

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7 January 2021

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

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7 January 2021

Protein tyrosine phosphatases

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7 January 2021

Protein tyrosine phosphatases as adhesion receptors

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7 January 2021

Switching signals on or off by receptor dimerization

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7 January 2021

Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

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7 January 2021

Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases alpha and epsilon

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7 January 2021

Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells

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7 January 2021

Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects

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7 January 2021

Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes

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7 January 2021

Dephosphorylation of autophosphorylated insulin and epidermal-growth-factor receptors by two major subtypes of protein-tyrosine-phosphatase from human placenta

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7 January 2021

Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system

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7 January 2021

Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes

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7 January 2021

Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway

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7 January 2021

Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue

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7 January 2021

High glucose condition activates protein tyrosine phosphatases and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts

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7 January 2021

Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities

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7 January 2021

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance

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7 January 2021

Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate-1 via different phosphotyrosine motifs

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7 January 2021

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

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7 January 2021

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

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7 January 2021

Structure, function, and regulation of the mammalian facilitative glucose transporter gene family

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7 January 2021

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site

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7 January 2021

A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation

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7 January 2021

The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.

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7 January 2021

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

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7 January 2021

Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture

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7 January 2021

Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.

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7 January 2021

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

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7 January 2021

Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells

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7 January 2021

Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells.

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7 January 2021

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

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7 January 2021

A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells

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7 January 2021

Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells

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7 January 2021

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

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7 January 2021

Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin

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7 January 2021

Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue

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7 January 2021

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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7 January 2021

Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway

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7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

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7 January 2021

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

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7 January 2021

Overexpression of protein tyrosine phosphatase-alpha (PTP-alpha) but not PTP-kappa inhibits translocation of GLUT4 in rat adipose cells

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7 January 2021

The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells

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7 January 2021

Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes

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7 January 2021

Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes

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7 January 2021

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

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7 January 2021

Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes

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7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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7 January 2021

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

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7 January 2021

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

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7 January 2021

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

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7 January 2021

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

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7 January 2021

Protein sorting by transport vesicles

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7 January 2021

Moving GLUT4: the biogenesis and trafficking of GLUT4 storage vesicles

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7 January 2021

The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells

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7 January 2021

Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes

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7 January 2021

Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport

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7 January 2021

Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4

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7 January 2021

Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling

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7 January 2021

Endocytosis of the glucose transporter GLUT4 is mediated by the GTPase dynamin

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7 January 2021

Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling?

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7 January 2021

The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase

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7 January 2021

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

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7 January 2021

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

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7 January 2021

Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes

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7 January 2021

Cross-talk between the insulin and angiotensin signaling systems

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Angiotensin II Stimulates Tyrosine Phosphorylation and Activation of Insulin Receptor Substrate 1 and Protein-tyrosine Phosphatase 1D in Vascular Smooth Muscle Cells

1 reference

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7 January 2021

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

G-protein-linked receptors as tyrosine kinase substrates: new paradigms in signal integration

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Caveolae and caveolins

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Molecular glue: kinase anchoring and scaffold proteins

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Baculovirus-based expression of mammalian caveolin in Sf21 insect cells. A model system for the biochemical and morphological study of caveolae biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

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https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

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7 January 2021

Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo

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7 January 2021

Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells

1 reference

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7 January 2021

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily

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7 January 2021

Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2899%2900025-X

7 January 2021

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

1 reference

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The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

1 reference

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7 January 2021

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

1 reference

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7 January 2021

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1 reference

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7 January 2021

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1 reference

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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

1 reference

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Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

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Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion

1 reference

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PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals

1 reference

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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1 reference

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7 January 2021

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

1 reference

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7 January 2021

10.1016/S0898-6568(99)00025-X

Identifiers

DOI

1 reference

28 July 2017

1 reference