(Q33706710)

28 July 2017

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title

The rationale and future potential of angiogenesis inhibitors in neoplasia (English)

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28 July 2017

main subject

angiogenesis inhibitor

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Gasparini G

1

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28 July 2017

publication date

1 July 1999

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28 July 2017

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28 July 2017

volume

58

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28 July 2017

issue

1

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28 July 2017

page(s)

17-38

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https://scigraph.springernature.com/pub.10.2165/00003495-199958010-00003

28 July 2017

exact match

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cites work

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Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin

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Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

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Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

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Molecular foundations of cancer: New targets for intervention

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There are no bad anticancer agents, only bad clinical trial designs--twenty-first Richard and Hinda Rosenthal Foundation Award Lecture.

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

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Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human p

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E-selectin is present in proliferating endothelial cells in human hemangiomas.

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The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin.

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Complete remission of metastatic cervical cancer with the angiogenesis inhibitor TNP-470

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Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma

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Stage-specific expression of integrin alphaVbeta3 in neuroblastic tumors.

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12 December 2020

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12 December 2020

bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells

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12 December 2020

Serum vascular endothelial growth factor is often elevated in disseminated cancer.

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12 December 2020

Angiogenesis inhibitors generated by tumors.

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12 December 2020

Modulation of the organ microenvironment for treatment of cancer metastasis

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12 December 2020

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

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12 December 2020

Mechanisms of angiogenesis

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12 December 2020

Natural killer cells, adhesion and tumor angiogenesis

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12 December 2020

Thalidomide is an inhibitor of angiogenesis

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12 December 2020

Behind the headlines of endostatin's ups and downs

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12 December 2020

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12 December 2020

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12 December 2020

SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts.

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12 December 2020

Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents

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12 December 2020

Are angiostatin and endostatin cures for cancer?

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12 December 2020

Inhibition of endothelial cell proliferation by gamma-interferon

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12 December 2020

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

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12 December 2020

In vitro inhibition of endothelial cell growth by the antiangiogenic drug AGM-1470 (TNP-470) and the anti-endoglin antibody TEC-11.

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12 December 2020

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

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12 December 2020

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.

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12 December 2020

Linomide blocks angiogenesis by breast carcinoma vascular endothelial growth factor transfectants

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12 December 2020

Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis.

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12 December 2020

A metalloproteinase inhibitor as an inhibitor of neovascularization

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12 December 2020

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

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12 December 2020

Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis

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12 December 2020

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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12 December 2020

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro.

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12 December 2020

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12 December 2020

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12 December 2020

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The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Combined effects of angiostatin and ionizing radiation in antitumour therapy

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12 December 2020

Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer

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12 December 2020

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

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12 December 2020

Inhibition of angiogenesis by thrombospondin-2

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12 December 2020

TNP-470 (AGM-1470): mechanisms of action and early clinical development.

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12 December 2020

What Is the Evidence That Tumors Are Angiogenesis Dependent?

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12 December 2020

The power of the front page of The New York Times

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12 December 2020

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules

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12 December 2020

A cancer therapy resistant to resistance

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12 December 2020

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

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12 December 2020

Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma

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12 December 2020

Blood platelets and serum VEGF in cancer patients

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12 December 2020

During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium

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12 December 2020

Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma

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12 December 2020

In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma

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12 December 2020

Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients

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12 December 2020

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

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12 December 2020

Oncogenes as inducers of tumor angiogenesis

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12 December 2020

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12 December 2020

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

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12 December 2020

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth

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12 December 2020

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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12 December 2020

Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

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12 December 2020

Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential

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12 December 2020

Protamine is an inhibitor of angiogenesis

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12 December 2020

beta-cyclodextrin tetradecasulfate/tetrahydrocortisol +/- minocycline as modulators of cancer therapies in vitro and in vivo against primary and metastatic Lewis lung carcinoma

1 reference

12 December 2020

How tumors become angiogenic

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12 December 2020

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

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12 December 2020

A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1.

1 reference

12 December 2020

Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD.

1 reference

12 December 2020

Angiogenesis antagonists: current clinical trials

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12 December 2020

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

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12 December 2020

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

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12 December 2020

Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature

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12 December 2020

Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma

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12 December 2020

Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.

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12 December 2020

The next frontier of molecular medicine: delivery of therapeutics.

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12 December 2020

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

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12 December 2020

Angiogenesis and colonization in the tumor metastatic process: basic and applied advances

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12 December 2020

Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer

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12 December 2020

Endothelial cell activation. A central pathophysiological process

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12 December 2020

Endothelial apoptosis in Braf-deficient mice

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12 December 2020

Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.

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12 December 2020

Control of angiogenesis with synthetic heparin substitutes

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12 December 2020

Biological properties of VEGF/VPF receptors

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12 December 2020

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation

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12 December 2020

Treating cancer by inhibiting angiogenesis: new hopes and potential pitfalls

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12 December 2020

Angiostatic steroids. Method of discovery and mechanism of action

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12 December 2020

Inhibition of angiogenesis in vivo by interleukin 12.

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12 December 2020

Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis

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12 December 2020

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas

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12 December 2020

Inhibition of tumor angiogenesis mediated by cartilage

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12 December 2020

Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis

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12 December 2020

Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470

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12 December 2020

Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic.

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12 December 2020

Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma

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12 December 2020

Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents

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12 December 2020

Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470).

1 reference

12 December 2020

Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma

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12 December 2020

The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression.

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12 December 2020

Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts

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12 December 2020

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

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12 December 2020

Matrix metalloproteinase inhibition: a review of anti-tumour activity

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12 December 2020

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

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12 December 2020

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

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12 December 2020

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor

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12 December 2020

The preclinical evaluation of angiogenesis inhibitors

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12 December 2020

Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy

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12 December 2020

Long-term culture of capillary endothelial cells

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12 December 2020

A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial

1 reference

12 December 2020

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

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12 December 2020

Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy

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12 December 2020

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

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12 December 2020

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

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12 December 2020

Quantitative angiogenesis assays: progress and problems

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12 December 2020

Role of transforming growth factor-[beta]1 in inhibiting endothelial cell proliferation in experimental alcoholic liver disease

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12 December 2020

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

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12 December 2020

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol

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12 December 2020

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

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12 December 2020

Reciprocal paracrine interactions between tumour cells and endothelial cells: the 'angiogenesis progression' hypothesis

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12 December 2020

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

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12 December 2020

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen

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12 December 2020

Leukemia inhibitory factor (LIF) inhibits angiogenesis in vitro

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12 December 2020

Progress towards a unifying hypothesis for angiogenesis

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12 December 2020

Matrix metalloproteinase inhibitors

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12 December 2020

Antitumor effect of the angiogenesis inhibitor agm-1470 and its combination effect with tamoxifen in dmba induced mammary-tumors in rats

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12 December 2020

Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

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12 December 2020

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents

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12 December 2020

The implications of angiogenesis for the biology and therapy of cancer metastasis

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12 December 2020

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

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12 December 2020

The microtubule-affecting drug paclitaxel has antiangiogenic activity

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12 December 2020

Cellular markers that distinguish the phases of hemangioma during infancy and childhood

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12 December 2020

Co-determination of the angiogenic factors thymidine phosphorylase and vascular endothelial growth factor in node-negative breast cancer: prognostic implications

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12 December 2020

Regulation of integrin function by the urokinase receptor

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12 December 2020

Radiation-induced apoptosis in microvascular endothelial cells

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12 December 2020

Regulation of angiogenesis by scatter factor.

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12 December 2020

10.2165/00003495-199958010-00003

Identifiers

DOI

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Dimensions Publication ID

28 July 2017

1032018164

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1 reference