(Q42590531)

3 November 2017

1 reference

8 February 2021

1 reference

PubMed publication ID

7710924

title

Interleukin 12: a new clinical player in cytokine therapy (English)

1 reference

Rosamonde Elizabeth Banks

3 November 2017

1 reference

20 November 2019

1 reference

8 February 2021

series ordinal

1

1 reference

3 November 2017

3

Selby PJ

1 reference

3 November 2017

Patel PM

2

1 reference

3 November 2017

language of work or name

English

0 references

publication date

1 April 1995

4 references

British Journal of Cancer

3 November 2017

3 April 2019

20 November 2019

8 February 2021

4 references

3 November 2017

3 April 2019

20 November 2019

8 February 2021

71

1 reference

3 November 2017

4

1 reference

3 November 2017

655-659

1 reference

https://scigraph.springernature.com/pub.10.1038/bjc.1995.130

3 November 2017

0 references

cites work

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28 May 2018

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Interleukin-12 and its role in the generation of TH1 cells

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Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

28 May 2018

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28 May 2018

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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

28 May 2018

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

28 May 2018

1 reference

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Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells

28 May 2018

1 reference

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Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

28 May 2018

1 reference

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Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells

28 May 2018

1 reference

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B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

28 May 2018

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Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

28 May 2018

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

28 May 2018

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Synergy between recombinant interleukin 2 (rIL 2) and IL 2-depleted lymphokine-containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro.

28 May 2018

1 reference

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Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

28 May 2018

1 reference

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Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

28 May 2018

1 reference

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Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

28 May 2018

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Natural killer cell stimulatory factor (NKSF) augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines

28 May 2018

1 reference

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Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

28 May 2018

1 reference

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Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

28 May 2018

1 reference

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IL-12 receptor. II. Distribution and regulation of receptor expression

28 May 2018

1 reference

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IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts

28 May 2018

1 reference

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Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

28 May 2018

1 reference

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IL-12 augments antigen-dependent proliferation of activated T lymphocytes

28 May 2018

1 reference

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Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Regulation of human cytolytic lymphocyte responses by interleukin-12

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Cloning and expression of murine IL-12

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Molecular characterization of interleukin 12

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Differential effects of interleukin-12 on the development of naive mouse CD4+ T cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033718

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes

1 December 2018

1 reference

12 December 2020

Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture

1 reference

12 December 2020

Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12

1 reference

12 December 2020

Immunomodulatory effects of interleukin-12 on human tumor-infiltrating lymphocytes

1 reference

12 December 2020

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

1 reference

12 December 2020

Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer

1 reference

12 December 2020

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection

1 reference

12 December 2020

Effect of human natural killer cells on the metastatic growth of human melanoma xenografts in mice with severe combined immunodeficiency

1 reference

12 December 2020

Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12

1 reference

12 December 2020

Effects of IL-12 on helper T cell-dependent immune responses in vivo

1 reference

12 December 2020

IL-12 influences intrathymic T cell development

1 reference

12 December 2020

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo

1 reference

12 December 2020

Interleukin-12 but not interferon-γ production correlates with induction of T helper type-1 phenotype in murine candidiasis

1 reference

12 December 2020

Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL

1 reference

12 December 2020

Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone

1 reference

12 December 2020

Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells

1 reference

12 December 2020

Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis

1 reference

12 December 2020

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production

1 reference

12 December 2020

Characterization of a factor(s) which synergizes with recombinant interleukin 2 in promoting allogeneic human cytolytic T-lymphocyte responses in vitro

1 reference

12 December 2020

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)

1 reference

12 December 2020

IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts

1 reference

12 December 2020

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.1995.130

1 reference

Dimensions Publication ID

3 November 2017

0 references

1 reference

3 November 2017

PubMed publication ID

7710924

1 reference