(Q33706897)

28 July 2017

Potential role of the 5-HT6 receptor in depression and anxiety: an overview of preclinical data (English)

1 reference

28 July 2017

0 references

Anna Wesołowska

1

1 reference

28 July 2017

1 July 2010

1 reference

28 July 2017

Pharmacological Reports

1 reference

28 July 2017

62

1 reference

28 July 2017

4

1 reference

28 July 2017

564-577

1 reference

Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice

28 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The neuropharmacology of various diazepam antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

A null mutation of the serotonin 6 receptor alters acute responses to ethanol

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Role of the serotonergic system in the forced swimming test

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Is the forced swimming test a suitable model for revealing antidepressant activity?

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Bi-phasic change in BDNF gene expression following antidepressant drug treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

In vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Potentiation of amphetamine-induced changes in dopamine and 5-HT by a 5-HT(6) receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Acute onset by 5-HT(6)-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-HT(6) receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Serotonergic modulation of the limbic system

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Acceleration of onset of action in schedule-induced polydipsia: combinations of SSRI and 5-HT1A and 5-HT1B receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Characterization of fluoxetine plus olanzapine treatment in rats: a behavior, endocrine, and immediate-early gene expression analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

A cholinergic-adrenergic hypothesis of mania and depression

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Metyrapone for depression and delirium secondary to Cushing's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

List of drugs in development for neurodegenerative diseases. Update June 2004.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Enlarged amygdala volume and reduced hippocampal volume in young women with major depression

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

GABAergic functions and depression: from classical therapies to herbal medicine

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The neurobiology and control of anxious states

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-HT6 receptors: a novel target for cognitive enhancement

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Neurobiology of depression

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine6 receptors in rat nucleus accumbens by antisense oligonucleotides.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Glutamate and depression: clinical and preclinical studies

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Antidepressant drug treatment induces Arc gene expression in the rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

GABA and mood disorders: a brief review and hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-Hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: a polymerase chain reaction study

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Nicotine and nicotinic receptor antagonists potentiate the antidepressant-like effects of imipramine and citalopram.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]SB-258585.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-HT6 receptor antagonists enhance retention of a water maze task in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Brain-derived neurotrophic factor and antidepressant activity

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Impairment of GABAergic transmission in depression: new insights from neuroimaging studies

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Choline transporters, cholinergic transmission and cognition

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Reduced hippocampal volume in drug-free depressed patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Relationship between regional distribution of imipramine and its effect on learned helplessness in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Nicotinic acetylcholine receptors as targets for antidepressants.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

mRNA expression of serotonin receptors in cells of the immune tissues of the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Hippocampal volume and depression: a meta-analysis of MRI studies

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Hippocampal volume in adult burn patients with and without posttraumatic stress disorder

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

1 reference

7 January 2021

Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Prolonged effect of an anesthetic dose of ketamine on behavioral despair

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

Central distribution and function of 5-HT6 receptor subtype in the rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970315-7

7 January 2021

10.1016/S1734-1140(10)70315-7

Identifiers

DOI

1 reference

28 July 2017

1 reference

PubMed ID

20884998