(Q33709310)

28 July 2017

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title

Genetically modified animals in pharmacological research: future trends (English)

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28 July 2017

Rudolph U

1

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28 July 2017

Möhler H

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

1 June 1999

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European Journal of Pharmacology

28 July 2017

published in

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28 July 2017

volume

375

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28 July 2017

issue

1-3

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28 July 2017

page(s)

327-337

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Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

28 July 2017

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7 January 2021

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Making the most of transgenic mice

7 January 2021

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Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

7 January 2021

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Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

7 January 2021

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Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.

7 January 2021

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Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination

7 January 2021

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Improved properties of FLP recombinase evolved by cycling mutagenesis

7 January 2021

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 January 2021

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Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

7 January 2021

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Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse

7 January 2021

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HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome

7 January 2021

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Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome.

7 January 2021

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

7 January 2021

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Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes

7 January 2021

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A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea

7 January 2021

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Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice.

7 January 2021

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Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.

7 January 2021

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Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

7 January 2021

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

7 January 2021

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HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

7 January 2021

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

7 January 2021

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Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice

7 January 2021

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Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

7 January 2021

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Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease

7 January 2021

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Positional cloning of the mouse circadian clock gene

7 January 2021

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

7 January 2021

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Humanized prion protein knock-in by Cre-induced site-specific recombination in the mouse

7 January 2021

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Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue.

7 January 2021

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Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

7 January 2021

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A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

7 January 2021

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Interleukin-10-deficient mice develop chronic enterocolitis

7 January 2021

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Inducible gene targeting in mice

7 January 2021

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Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

7 January 2021

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Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

7 January 2021

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Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

7 January 2021

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7 January 2021

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Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

7 January 2021

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Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

7 January 2021

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Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

7 January 2021

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Inducible and reversible gene expression with the rtTA system for the study of memory

7 January 2021

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An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

7 January 2021

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Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

7 January 2021

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Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivo

7 January 2021

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Defective platelet activation in G alpha(q)-deficient mice.

7 January 2021

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Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I.

7 January 2021

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Ex vivo hepatic gene therapy of a mouse model of Hereditary Tyrosinemia Type I.

7 January 2021

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DNA binding of the glucocorticoid receptor is not essential for survival

7 January 2021

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Sustained somatic gene inactivation by viral transfer of Cre recombinase.

7 January 2021

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Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

7 January 2021

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Optimizing the mouse to sift sequence for function

7 January 2021

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Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice.

7 January 2021

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A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds

7 January 2021

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

7 January 2021

1 reference

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Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice.

7 January 2021

1 reference

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Manipulation of transgenes by site-specific recombination: use of Cre recombinase

7 January 2021

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Temporally and spatially regulated somatic mutagenesis in mice

7 January 2021

1 reference

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Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900195-8

Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice

7 January 2021

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

7 January 2021

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Forward and reverse genetic approaches to behavior in the mouse

7 January 2021

1 reference

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Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900195-8

Subregion- and cell type-restricted gene knockout in mouse brain

7 January 2021

1 reference

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The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900195-8

Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2899%2900195-8

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

7 January 2021

1 reference

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Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene

7 January 2021

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Transgenic animals as new approaches in pharmacological studies

7 January 2021

1 reference

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Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

7 January 2021

1 reference

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Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions

7 January 2021

1 reference

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10.1016/S0014-2999(99)00195-8

7 January 2021

Identifiers

DOI

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28 July 2017

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