(Q33713446)

28 July 2017

title

Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects (English)

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28 July 2017

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Chan Il Chang

1

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28 July 2017

Jae Wook Yoo

2

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28 July 2017

Sun Woo Hong

3

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28 July 2017

Shi Eun Lee

4

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28 July 2017

Hye Suk Kang

5

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28 July 2017

Xiangao Sun

6

1 reference

28 July 2017

Harry A Rogoff

7

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28 July 2017

Changill Ban

8

1 reference

28 July 2017

Soyoun Kim

9

1 reference

28 July 2017

Chiang J Li

10

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28 July 2017

Dong-Ki Lee

11

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28 July 2017

publication date

20 January 2009

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28 July 2017

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28 July 2017

volume

17

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28 July 2017

issue

4

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28 July 2017

page(s)

725-732

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Potent RNAi by short RNA triggers.

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Competition potency of siRNA is specified by the 5'-half sequence of the guide strand

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Competition for RISC binding predicts in vitro potency of siRNA.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

siRNA and isRNA: two edges of one sword

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Inflammatory cytokine induction by siRNAs is cell type- and transfection reagent-specific

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Criteria for effective design, construction, and gene knockdown by shRNA vectors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Functional polarity is introduced by Dicer processing of short substrate RNAs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Cell division and cell survival in the absence of survivin

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Functional siRNAs and miRNAs Exhibit Strand Bias

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Asymmetry in the assembly of the RNAi enzyme complex

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Expression profiling reveals off-target gene regulation by RNAi

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Survivin, cancer networks and pathway-directed drug discovery.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Chemical modification of siRNAs to improve serum stability without loss of efficacy.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835116

Noise amidst the silence: off-target effects of siRNAs?

30 October 2018

1 reference

PubMed

12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

A structure-activity relationship study of siRNAs with structural variations

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/MT.2008.298

1 reference

28 July 2017

1 reference

28 July 2017

1 reference