(Q33713758)

28 July 2017

title

Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A. (English)

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28 July 2017

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Christopher B Doering

1

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28 July 2017

Gabriela Denning

2

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28 July 2017

Kerry Dooriss

3

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28 July 2017

Bagirath Gangadharan

4

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28 July 2017

Jennifer M Johnston

5

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28 July 2017

Keith W Kerstann

6

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28 July 2017

David A McCarty

7

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28 July 2017

H Trent Spencer

8

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28 July 2017

publication date

3 March 2009

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28 July 2017

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28 July 2017

volume

17

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28 July 2017

issue

7

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28 July 2017

page(s)

1145-1154

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describes a project that uses

28 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2835206/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens

21 June 2018

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Gene therapy, bioengineered clotting factors and novel technologies for hemophilia treatment

21 June 2018

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Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A.

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Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibalpha promoter: in vivo model for platelet-targeting gene therapy.

21 June 2018

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Stability and homogeneity of transgene expression in isogenic cells

21 June 2018

1 reference

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Correction of murine hemophilia A by hematopoietic stem cell gene therapy

21 June 2018

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Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer

21 June 2018

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Sustained phenotypic correction of hemophilia a mice following oncoretroviral-mediated expression of a bioengineered human factor VIII gene in long-term hematopoietic repopulating cells

21 June 2018

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21 June 2018

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Bioengineering of coagulation factor VIII for improved secretion

21 June 2018

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Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells.

21 June 2018

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Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.

21 June 2018

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High level expression of recombinant porcine coagulation factor VIII.

21 June 2018

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21 June 2018

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Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice

21 June 2018

1 reference

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Sustained expression of human factor VIII in mice using a parvovirus-based vector.

21 June 2018

1 reference

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Coexpression of factor VIII heavy and light chain adeno-associated viral vectors produces biologically active protein

21 June 2018

1 reference

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Genetic induction of immune tolerance to human clotting factor VIII in a mouse model for hemophilia A

21 June 2018

1 reference

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Bone marrow stromal cells as targets for gene therapy of hemophilia A.

21 June 2018

1 reference

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Characterization of the human factor VIII gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Phenotypic correction of a mouse model of hemophilia A using AAV2 vectors encoding the heavy and light chains of FVIII.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Efficient production of human FVIII in hemophilic mice using lentiviral vectors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835206

Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19259064

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene therapy for haemophilia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19259064

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MT.2009.35

1 reference

28 July 2017

1 reference

28 July 2017

1 reference