(Q33717472)

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Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

photoreceptor protein

0 references

author name string

Xiu-Jun Zhang

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Nikolai P Skiba

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Rick H Cote

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

0 references

publication date

30 November 2009

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

number of pages

9

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

4455-4463

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

The retinal cGMP phosphodiesterase gamma-subunit - a chameleon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Signal transducing membrane complexes of photoreceptor outer segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Intrinsically disordered -subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Phototransduction in mouse rods and cones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Binding of cGMP to GAF domains in amphibian rod photoreceptor cGMP phosphodiesterase (PDE). Identification of GAF domains in PDE alphabeta subunits and distinct domains in the PDE gamma subunit involved in stimulation of cGMP binding to GAF domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

G proteins and phototransduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

In vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

A point mutation (W70A) in the rod PDE-gamma gene desensitizing and delaying murine rod photoreceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Binding of transducin to light-activated rhodopsin prevents transducin interaction with the rod cGMP phosphodiesterase gamma-subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Mechanism of photoreceptor cGMP phosphodiesterase inhibition by its gamma-subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

A site on transducin alpha-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Measurement of protein using bicinchoninic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Mechanistic studies on rhodopsin kinase. Light-dependent phosphorylation of C-terminal peptides of rhodopsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Functional regions of the inhibitory subunit of retinal rod cGMP phosphodiesterase identified by site-specific mutagenesis and fluorescence spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

Domain mapping of the retinal cyclic GMP phosphodiesterase γ-subunit. Function of the domains encoded by the three exons of the γ-subunit gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

21 June 2018

An interface of interaction between photoreceptor cGMP phosphodiesterase catalytic subunits and inhibitory gamma subunits.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

Effect of zinc and temperature on the conformation of the gamma subunit of retinal phosphodiesterase: a natively unfolded protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

Loss of the Effector Function in a Transducin-α Mutant Associated with Nougaret Night Blindness

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.057406

21 January 2018

Purification, reconstitution on lipid vesicles, and assays of PDE6 and its activator G protein, transducin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

30 October 2018

Cyclic guanosine 5'-monophosphate binding to regulatory GAF domains of photoreceptor phosphodiesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

30 October 2018

Purification of PDE6 isozymes from mammalian retina

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836051

30 October 2018

Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of the cGMP phosphodiesterase gamma subunit from bovine rod outer segments: role of separate amino acid residues in the interaction with catalytic subunits and transducin alpha subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma subunit of rod cGMP-phosphodiesterase blocks the enzyme catalytic site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural features of the noncatalytic cGMP binding sites of frog photoreceptor phosphodiesterase using cGMP analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for the target enzyme in deactivation of photoreceptor G protein in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phototransduction in a transgenic mouse model of Nougaret night blindness

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolution of transducin subunits by chromatography on blue sepharose

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active sites of the cyclic GMP phosphodiesterase gamma-subunit of retinal rod outer segments

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the gamma-subunit of retinal rod outer segment phosphodiesterase with transducin. Use of synthetic peptides as functional probes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19948718

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.057406

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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