(Q33720954)

28 July 2017

Hybrid scoring and classification approaches to predict human pregnane X receptor activators (English)

1 reference

28 July 2017

4

1 reference

28 July 2017

Sandhya Kortagere

1

1 reference

28 July 2017

Dmitriy Chekmarev

series ordinal

2

1 reference

28 July 2017

William J Welsh

series ordinal

3

1 reference

28 July 2017

language of work or name

1 reference

30 December 2008

1 reference

28 July 2017

Pharmaceutical Research

1 reference

28 July 2017

26

1 reference

28 July 2017

1001-1011

1 reference

28 July 2017

4

1 reference

Machine learning methods and docking for predicting human pregnane X receptor activation

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Shape signatures: new descriptors for predicting cardiotoxicity in silico

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

New predictive models for blood-brain barrier permeability of drug-like molecules

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

In silico tools to aid risk assessment of endocrine disrupting chemicals

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Structural insights into the promiscuity and function of the human pregnane X receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Development and validation of a genetic algorithm for flexible docking

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Comparison of the predicted and observed secondary structure of T4 phage lysozyme

14 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

14 July 2018

https://api.crossref.org/works/10.1007%2FS11095-008-9809-7

Prediction of P-glycoprotein substrates by a support vector machine approach.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11095-008-9809-7

Unsupervised forward selection: a method for eliminating redundant variables.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11095-008-9809-7

A novel approach using pharmacophore ensemble/support vector machine (PhE/SVM) for prediction of hERG liability.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

In silico prediction of pregnane X receptor activators by machine learning approaches.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Multifingerprint based similarity searches for targeted class compound selection.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

A combined approach to drug metabolism and toxicity assessment

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocols

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

The identification of ligand features essential for PXR activation by pharmacophore modeling

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Enrichment of ligands for the serotonin receptor using the Shape Signatures approach

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

PXR and the regulation of apoA1 and HDL-cholesterol in rodents

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Shape signatures: a new approach to computer-aided ligand- and receptor-based drug design

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

A pharmacophore for human pregnane X receptor ligands

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836910

Structure-based drug discovery using GPCR homology modeling: successful virtual screening for antagonists of the alpha1A adrenergic receptor

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19115096

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19115096

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11095-008-9809-7

1 reference

28 July 2017

1 reference

28 July 2017

1 reference