(Q33739184)

29 July 2017

Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition (English)

1 reference

triple-negative breast cancer

29 July 2017

1 reference

1 reference

1 reference

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Shanaz Dairkee

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Banafshé Larijani

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Stefanie S Jeffrey

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Haiyu Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Adam L Cohen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Sujatha Krishnakumar

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Irene L Wapnir

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Selvaraju Veeriah

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Glenn Deng

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Marc A Coram

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Caroline M Piskun

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Teri A Longacre

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Michael Herrler

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Daniel O Frimannsson

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Melinda L Telli

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Frederick M Dirbas

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Gennadi V Glinsky

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Andrea H Bild

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

7 April 2014

1 reference

29 July 2017

Breast Cancer Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

R36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1186/bcr3640

13 June 2020

exact match

0 references

cites work

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21 June 2018

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A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models

21 June 2018

1 reference

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Combined targeting of mTOR and AKT is an effective strategy for basal-like breast cancer in patient-derived xenograft models

21 June 2018

1 reference

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Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer

21 June 2018

1 reference

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Molecular characterization of basal-like and non-basal-like triple-negative breast cancer

21 June 2018

1 reference

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Patient-derived breast tumor xenografts facilitating personalized cancer therapy

21 June 2018

1 reference

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VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer

21 June 2018

1 reference

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Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer

21 June 2018

1 reference

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Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models

21 June 2018

1 reference

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PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials

21 June 2018

1 reference

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Comprehensive molecular portraits of human breast tumours

21 June 2018

1 reference

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Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors

21 June 2018

1 reference

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NIH Image to ImageJ: 25 years of image analysis

21 June 2018

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TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer.

21 June 2018

1 reference

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Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures

21 June 2018

1 reference

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mTOR signaling in growth control and disease

21 June 2018

1 reference

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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

21 June 2018

1 reference

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PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors

21 June 2018

1 reference

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Molecular profiling of patient-derived breast cancer xenografts

21 June 2018

1 reference

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Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

21 June 2018

1 reference

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Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study

21 June 2018

1 reference

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Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer

21 June 2018

1 reference

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A genomic approach to predict synergistic combinations for breast cancer treatment

21 June 2018

1 reference

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Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model

21 June 2018

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Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

21 June 2018

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A pharmacogenomic method for individualized prediction of drug sensitivity

21 June 2018

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A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer

21 June 2018

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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

21 June 2018

1 reference

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PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

21 June 2018

1 reference

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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

21 June 2018

1 reference

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Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

21 June 2018

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Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis

21 June 2018

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Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models

21 June 2018

1 reference

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Genome remodelling in a basal-like breast cancer metastasis and xenograft

21 June 2018

1 reference

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Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

21 June 2018

1 reference

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Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study

21 June 2018

1 reference

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Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

21 June 2018

1 reference

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The rapamycin-regulated gene expression signature determines prognosis for breast cancer

21 June 2018

1 reference

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PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

21 June 2018

1 reference

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Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

21 June 2018

1 reference

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

21 June 2018

1 reference

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

21 June 2018

1 reference

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

21 June 2018

1 reference

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How basal are triple-negative breast cancers?

21 June 2018

1 reference

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

21 June 2018

1 reference

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

21 June 2018

1 reference

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Triple-negative breast cancer: clinical features and patterns of recurrence

21 June 2018

1 reference

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A new model of patient tumor-derived breast cancer xenografts for preclinical assays

21 June 2018

1 reference

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AKT/PKB signaling: navigating downstream

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

The molecular portraits of breast tumors are conserved across microarray platforms

21 June 2018

1 reference

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

An expanding role for mTOR in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Molecular portraits of human breast tumours

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group.

21 June 2018

1 reference

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

21 January 2018

1 reference

PB.20. Audit of 5 years of routine screening mammography of the reconstructed breast.

21 January 2018

1 reference

Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes.

21 January 2018

1 reference

Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163.

21 January 2018

1 reference

The pharmacology of mTOR inhibition

21 January 2018

1 reference

mTOR signaling, function, novel inhibitors, and therapeutic targets.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4053092

A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors

30 October 2018

1 reference

12 December 2020

Targeting mTOR for cancer treatment

1 reference

12 December 2020

Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery

1 reference

12 December 2020

Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts

1 reference

12 December 2020

Identifiers

DOI

10.1186/BCR3640

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/bcr3640

9 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24708766%20AND%20SRC:MED&resulttype=core&format=json