(Q33742314)

29 July 2017

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title

Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis (English)

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29 July 2017

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F J Gonzalez

1

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29 July 2017

S Kimura

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 September 1999

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29 July 2017

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29 July 2017

volume

143

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29 July 2017

issue

2

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29 July 2017

page(s)

199-204

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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

29 July 2017

cites work

1 reference

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7 January 2021

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer

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Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation

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7 January 2021

Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species

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7 January 2021

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

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7 January 2021

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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7 January 2021

Cytochrome P-4502E1: its physiological and pathological role

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7 January 2021

Epoxide hydratase: sex specific expression and rate-limiting role in DMBA metabolism

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7 January 2021

Cytochromes P450 expression systems

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7 January 2021

Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues

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7 January 2021

Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans

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7 January 2021

Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a

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7 January 2021

Neonatal mouse assay for tumorigenicity: alternative to the chronic rodent bioassay.

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Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance: 1996 update

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7 January 2021

Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat

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7 January 2021

Acetaminophen hepatotoxicity

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7 January 2021

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

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7 January 2021

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

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7 January 2021

Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2

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7 January 2021

A Novel Adrenocorticotropin-Inducible Cytochrome P450 from Rat Adrenal Microsomes Catalyzes Polycylic Aromatic Hydrocarbon Metabolism*

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7 January 2021

Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells

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7 January 2021

Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens

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7 January 2021

Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta

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7 January 2021

Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation

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7 January 2021

Chemoprotection against cancer by phase 2 enzyme induction

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7 January 2021

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

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7 January 2021

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).

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7 January 2021

Antiepileptic drug therapy and reproductive consequences: functional and morphologic effects

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7 January 2021

Polycyclic hydrocarbon activation: bay regions and beyond

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7 January 2021

Mechanism of metabolic activation of the potent carcinogen 7,12-dimethylbenz[a]anthracene

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7 January 2021

Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen.

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7 January 2021

10.1016/S0304-3835(99)00125-1

Identifiers

DOI

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29 July 2017

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