(Q41670058)

6 October 2017

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title

Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species (English)

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6 October 2017

Guengerich FP

1

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6 October 2017

publication date

1 October 1997

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Chemico-biological Interactions

6 October 2017

published in

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6 October 2017

volume

106

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6 October 2017

issue

3

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6 October 2017

page(s)

161-182

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Effects of individual mutations in the P-450(C21) pseudogene on the P-450(C21) activity and their distribution in the patient genomes of congenital steroid 21-hydroxylase deficiency

6 October 2017

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Regulation of steroid hydroxylase gene expression: importance to physiology and disease

7 January 2021

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The vitamin D story: a collaborative effort of basic science and clinical medicine.

7 January 2021

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

7 January 2021

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Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

7 January 2021

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Highly purified cytochrome P-448 and P-450 from rat liver microsomes

7 January 2021

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The P450 gene superfamily: recommended nomenclature.

7 January 2021

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The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci

7 January 2021

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The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

7 January 2021

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Some DNA targets of the yeast CYP1 transcriptional activator are functionally asymmetric--evidence of two half-sites with different affinities

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Constitutive and inducible expression of human cytochrome P450IA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Drug metabolism by Escherichia coli expressing human cytochromes P450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Ligand binding studies of engineered cytochrome P-450d wild type, proximal mutants, and distal mutants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Mutations at the distal and proximal sites of cytochrome P-450d changed regio-specificity of acetanilide hydroxylations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

CO binding studies of engineered cytochrome P-450ds: effects of mutations at putative distal sites in the presence of polycyclic hydrocarbons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of Glu318 and Thr319 in the catalytic function of cytochrome P450d (P4501A2): effects of mutations on the methanol hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Absorption spectral study of cytochrome P450d-phenyl isocyanide complexes: effects of mutations at the putative distal site on the conformational stability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of Glu318 at the putative distal site in the catalytic function of cytochrome P450d

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Site-directed mutageneses of rat liver cytochrome P-450d: catalytic activities toward benzphetamine and 7-ethoxycoumarin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Studies on the mutagenic activation of heterocyclic amines by cynomolgus monkey, rat and human microsomes show that cynomolgus monkeys have a low capacity to N-oxidize the quinoxaline-type heterocyclic amines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The structure, function, and regulation of cytochrome P450 2A enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Multiplicity strain differences, and topology of phenobarbital-induced cytochromes P-450 in rat liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Cytochrome P-450 purified to apparent homogeneity from phenobarbital-induced rabbit liver microsomes: catalytic activity and other properties

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Analysis of the catalytic specificity of cytochrome P450 enzymes through site-directed mutagenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The molecular genetics of 21-hydroxylase deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Further studies on chimeric P450 2C2/2C14 having testosterone 16 beta-hydroxylase activity which is absent in the parental P450s

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Constitutive expression and hormonal regulation of male sexually differentiated cytochromes P450 in primary cultured rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Polymorphic hydroxylation of Debrisoquine in man.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Cytochrome P450IID subfamily in non-human primates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Acetone-inducible cytochrome P-450: purification, catalytic activity, and interaction with cytochrome b5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

A hypothetical model for the active site of human cytochrome P4502E1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Interpretations of cytochrome P450 mechanisms from kinetic studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Purification and characterization of cytochrome P450 2E2 from hepatic microsomes of neonatal rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Fetus-specific expression of a form of cytochrome P-450 in human livers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Purification and properties of cytochrome P-450 from homogenates of human fetal livers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Expression of CYP3A7, a human fetus-specific cytochrome P450, in cultured cells and in the hepatocytes of p53-knockout mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Dissociation of Hydroxylase and Lyase Activities by Site-Directed Mutagenesis of the Rat P45017α

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Construction and expression of human/bovine P45017 alpha chimeric proteins: evidence for distinct tertiary structures in the same P450 from two different species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Cytochrome P450 4A4: expression in Escherichia coli, purification, and characterization of catalytic properties.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Expression of rabbit cytochromes P4504A which catalyze the omega-hydroxylation of arachidonic acid, fatty acids, and prostaglandins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0009-2797%2897%2900068-9

10.1016/S0009-2797(97)00068-9

7 January 2021

Identifiers

DOI

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6 October 2017

1 reference