(Q54561454)

31 May 2018

title

Drug metabolism by Escherichia coli expressing human cytochromes P450 (English)

1 reference

11 November 2024

0 references

2

E. M. Gillam

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9255795

11 November 2024

author name string

A. Parikh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9255795

11 November 2024

F. P. Guengerich

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9255795

11 November 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9255795

11 November 2024

publication date

1 August 1997

1 reference

31 May 2018

August 1997

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9255795

full work available at URL

11 November 2024

http://www.nature.com/articles/nbt0897-784

1 reference

http://www.nature.com/articles/nbt0897-784.pdf

11 November 2024

file format

Portable Document Format

1 reference

11 November 2024

1 reference

31 May 2018

volume

15

1 reference

31 May 2018

issue

8

1 reference

31 May 2018

page(s)

784-788

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31 May 2018

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

cites work

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7 January 2021

Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.

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7 January 2021

A genetically engineered P450 monooxygenase: construction of the functional fused enzyme between rat cytochrome P450c and NADPH-cytochrome P450 reductase

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7 January 2021

Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase

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Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification

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7 January 2021

Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:rat NADPH-cytochrome P450 reductase fusion protein.

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7 January 2021

Bicistronic and two-gene retroviral vectors for using MDR1 as a selectable marker and a therapeutic gene

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Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

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7 January 2021

Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions

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7 January 2021

Production of mature bovine pancreatic ribonuclease in Escherichia coli

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7 January 2021

Coexpression of mammalian cytochrome P450 and reductase in Escherichia coli

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Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

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7 January 2021

The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17.

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7 January 2021

New applications of bacterial systems to problems in toxicology.

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Purification of functional recombinant P450s from bacteria

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7 January 2021

Immunological comparison of rat, rabbit, and human liver NADPH-cytochrome P-450 reductases

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7 January 2021

Expression of a functional 78,000 dalton mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli

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7 January 2021

Expression of heterologous proteins in Escherichia coli

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7 January 2021

Vector for enhanced translation of foreign genes in Escherichia coli

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7 January 2021

Enhanced translational efficiency with two-cistron expression system.

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7 January 2021

Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins)

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7 January 2021

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

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7 January 2021

Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization

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7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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7 January 2021

Silver staining of proteins in polyacrylamide gels

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7 January 2021

Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli.

1

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11 November 2024

3

55

799

PD Josephy

1995

1 reference

Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities.

11 November 2024

5

1 reference

11 November 2024

Molecular Pharmacology

25

3

113

JB Schenkman

1967

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Drug Metabolism and Disposition

11 November 2024

32

3

245

MD Burke

1975

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Journal of Pharmacology and Experimental Therapeutics

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35

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RG Knodell

1987

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11 November 2024

Identifiers

DOI

10.1038/NBT0897-784

1 reference

31 May 2018

1 reference

31 May 2018