(Q33763151)

29 July 2017

title

Energetics of gating at the apo-acetylcholine receptor transmitter binding site (English)

1 reference

29 July 2017

Prasad Purohit

1

1 reference

29 July 2017

Anthony Auerbach

series ordinal

2

1 reference

29 July 2017

publication date

1 April 2010

1 reference

The Journal of General Physiology

29 July 2017

published in

1 reference

29 July 2017

volume

135

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29 July 2017

issue

4

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29 July 2017

page(s)

321-331

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Acetylcholine receptor channels activated by a single agonist molecule

29 July 2017

cites work

1 reference

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The gating isomerization of neuromuscular acetylcholine receptors

28 July 2018

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Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels

28 July 2018

1 reference

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Unliganded gating of acetylcholine receptor channels

28 July 2018

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Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain

28 July 2018

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Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker

28 July 2018

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Recent advances in Cys-loop receptor structure and function

28 July 2018

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Dynamics of the acetylcholine receptor pore at the gating transition state

28 July 2018

1 reference

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Phi-value analysis of a linear, sequential reaction mechanism: theory and application to ion channel gating

28 July 2018

1 reference

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Tryptophan side chain electrostatic interactions determine edge-to-face vs parallel-displaced tryptophan side chain geometries in the designed beta-hairpin "trpzip2".

28 July 2018

1 reference

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

28 July 2018

1 reference

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Gating of acetylcholine receptor channels: brownian motion across a broad transition state

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Cys-loop receptors: new twists and turns

28 July 2018

1 reference

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

28 July 2018

1 reference

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Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels

28 July 2018

1 reference

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The role of loop 5 in acetylcholine receptor channel gating.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Emerging structure of the nicotinic acetylcholine receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Mapping the conformational wave of acetylcholine receptor channel gating

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

A mutational analysis of the acetylcholine receptor channel transmitter binding site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

The nature of cation-pi binding: interactions between tetramethylammonium ion and benzene in aqueous solution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Spontaneous openings of the acetylcholine receptor channel

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Kinetics of unliganded acetylcholine receptor channel gating

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Energy and structure of the M2 helix in acetylcholine receptor-channel gating.

28 July 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Tryptophan-containing peptide helices: interactions involving the indole side chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Detection and trapping of intermediate states priming nicotinic receptor channel opening

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Maximum likelihood estimation of aggregated Markov processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Mapping the structural requirements for nicotinic acetylcholine receptor activation by using tethered alkyltrimethylammonium agonists and antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.200910384

Allosteric transitions of the acetylcholine receptor.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2847916

Packing of aromatic rings against tryptophan residues in proteins

30 October 2018

1 reference

12 December 2020

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

1 reference

12 December 2020

Ligand-receptor interactions in the nicotinic acetylcholine receptor probed using multiple substitutions at conserved tyrosines on the alpha subunit

1 reference

12 December 2020

Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor

1 reference

12 December 2020

Identifiers

DOI

10.1085/JGP.200910384

1 reference

29 July 2017

1 reference

29 July 2017

1 reference