(Q33767514)

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PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer

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Europe PubMed Central

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29 July 2017

PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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Chao Wang

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Jinling Jiang

2

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Europe PubMed Central

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29 July 2017

Jun Ji

3

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Europe PubMed Central

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29 July 2017

Qu Cai

4

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Europe PubMed Central

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29 July 2017

Xuehua Chen

5

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Europe PubMed Central

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29 July 2017

Yingyan Yu

6

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Europe PubMed Central

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29 July 2017

Zhenggang Zhu

7

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Europe PubMed Central

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29 July 2017

Jun Zhang

8

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29 July 2017

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publication date

6 June 2017

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Europe PubMed Central

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29 July 2017

Scientific Reports

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29 July 2017

7

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Europe PubMed Central

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29 July 2017

1

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Europe PubMed Central

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29 July 2017

2886

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Creative Commons Attribution 4.0 International

6 June 2017

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April 2022 Public Data File from Crossref

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https://scigraph.springernature.com/pub.10.1038/s41598-017-03031-1

0 references

Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro

1 reference

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14 July 2018

PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer

1 reference

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14 July 2018

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

1 reference

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14 July 2018

Functional role of autophagy in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1

1 reference

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14 July 2018

Cancer statistics in China, 2015.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

1 reference

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14 July 2018

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

1 reference

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14 July 2018

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

1 reference

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14 July 2018

Targeting autophagy to overcome drug resistance in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Pyruvate kinase: Function, regulation and role in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Knockdown of PKM2 induces apoptosis and autophagy in human A549 alveolar adenocarcinoma cells

1 reference

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14 July 2018

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Global cancer statistics, 2012

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 contributes to cancer metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Gene-expression signatures can distinguish gastric cancer grades and stages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

14 July 2018

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5460252

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Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

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14 July 2018

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

1 reference

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14 July 2018

Oncogenic pathway combinations predict clinical prognosis in gastric cancer.

1 reference

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14 July 2018

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition.

1 reference

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1 reference

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Gene-expression profiles predict survival of patients with lung adenocarcinoma

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.

1 reference

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30 October 2018

Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway

1 reference

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30 October 2018

Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo.

1 reference

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Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study.

1 reference

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Upregulated INHBA expression is associated with poor survival in gastric cancer.

1 reference

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30 October 2018

Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors

1 reference

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30 October 2018

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10.1038/S41598-017-03031-1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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