(Q33775518)

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Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition

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18 January 2020

Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition (English)

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18 January 2020

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18 January 2020

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Weiguo Chen

1

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18 January 2020

Lawrence J Druhan

2

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18 January 2020

Chun-An Chen

3

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18 January 2020

Yeong-Renn Chen

5

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18 January 2020

Vladimir Berka

6

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18 January 2020

Ah-Lim Tsai

7

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18 January 2020

Jay L Zweier

8

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18 January 2020

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1 April 2010

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18 January 2020

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18 January 2020

49

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18 January 2020

3129-3137

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18 January 2020

14

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18 January 2020

In vivo atherosclerotic plaque characterization using magnetic susceptibility distinguishes symptom-producing plaques

1 reference

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4 July 2018

Chemical biology of peroxynitrite: kinetics, diffusion, and radicals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate

1 reference

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4 July 2018

Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase

1 reference

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4 July 2018

Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice

1 reference

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4 July 2018

Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

S-Nitrosation and regulation of inducible nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus.

1 reference

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4 July 2018

S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity

1 reference

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4 July 2018

Caveolin regulation of endothelial function

1 reference

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4 July 2018

Endothelial nitric oxide synthase and endothelial dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Targeting sources of superoxide and increasing nitric oxide bioavailability in hypertension

1 reference

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4 July 2018

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Redox properties of human endothelial nitric-oxide synthase oxygenase and reductase domains purified from yeast expression system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Inactivation of the inducible nitric oxide synthase by peroxynitrite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Superoxide and peroxynitrite in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Nitric oxide: pathophysiological mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

4 July 2018

Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Structure of a loose dimer: an intermediate in nitric oxide synthase assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Reaction of ferric cytochrome P450cam with peracids: kinetic characterization of intermediates on the reaction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide syntha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Evidence for a bidomain structure of constitutive cerebellar nitric oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2851177

30 October 2018

Characterization of Recombinant Human Endothelial Nitric-oxide Synthase Purified from the YeastPichia pastoris

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite inhibition of nitric oxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of various imidazole ligands on heme conformation in endothelial nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc content of Escherichia coli-expressed constitutive isoforms of nitric-oxide synthase. Enzymatic activity and effect of pterin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxynitrite reaction with heme proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels

1 reference

https://pubmed.ncbi.nlm.nih.gov/20184376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI9016632

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184376%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184376%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20184376%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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