(Q33787464)

29 July 2017

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title

Aging, DNA methylation and cancer (English)

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29 July 2017

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Issa JP

1

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29 July 2017

language of work or name

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1 September 1999

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Critical Reviews in Oncology Hematology

29 July 2017

published in

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29 July 2017

volume

32

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29 July 2017

issue

1

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29 July 2017

page(s)

31-43

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Cancer in older persons. Magnitude of the problem--how do we apply what we know?

29 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Cancer in the elderly. Epidemiologic and clinical implications.

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7 January 2021

Aging and Cancer: Issues of Basic and Clinical Science

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7 January 2021

Cancer statistics, 1998.

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7 January 2021

Lessons from hereditary colorectal cancer

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7 January 2021

Oxidants, antioxidants, and the degenerative diseases of aging

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https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Involvement of DNA repair in cancer and aging

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https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA damage, mutation and fine structure DNA repair in aging.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

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https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Telomeres shorten during ageing of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Telomere reduction in human colorectal carcinoma and with ageing

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https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Aging and cancer: are telomeres and telomerase the connection?

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Telomerase activity, cell proliferation, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Replicative senescence: implications for in vivo aging and tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Expression genetics in cancer: shifting the focus from DNA to RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA Methylation and Gene Function

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Dna Methylation in Eukaryote

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation and gene activity

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation in early development

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

The essentials of DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Localization of methylation sites in the human O6-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Cytosine methylation and mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

1 reference

7 January 2021

DNA methylation and chromatin structure

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA hypomethylation leads to elevated mutation rates

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Transcriptional silencing of human Alu sequences and inhibition of protein binding in the box B regulatory elements by 5'-CG-3' methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Creation of genomic methylation patterns

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

CpG islands and genes

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Formation of methylation patterns in the mammalian genome

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

X-chromosome inactivation in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation and genomic imprinting

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Reactivation of inactive X-linked genes

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Gametic imprinting in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Role for DNA methylation in genomic imprinting

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Effects of DNA methylation on DNA-binding proteins and gene expression.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

How does DNA methylation repress transcription?

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Isolation and characterization of the cDNA encoding human DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Cloning and analysis of a novel human putative DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

The 5-methylcytosine content of DNA from human tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Decreased methylation of the major mouse long interspersed repeated DNA during aging and in myeloma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Inhibition of DNA methylation by chemical carcinogens in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methyl group deficiency in hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Characterization of DNA methylation in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA hypomethylation in ethionine-induced rat preneoplastic hepatocyte nodules

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Genomic 5-methyldeoxycytidine decreases associated with the induction of squamous differentiation in cultured normal human bronchial epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Hypomethylation of ras oncogenes in primary human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Hypomethylation of DNA from benign and malignant human colon neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of c-myc gene changes in human lymphoproliferative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Changes in methylation pattern of albumin and α-fetoprotein genes in developing rat liver and neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA demethylation and pericentromeric rearrangements of chromosome 1

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation and genetic instability in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Genetic instability in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Effects of 5-azacytidine in syrian golden hamsters: Toxicity, tumorigenicity, and differential modulation of bronchial carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Increased cytosine DNA-methyltransferase activity during colon cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Intracellular distribution of DNA methyltransferase during the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation and silencing of the Thrombospondin-1 promoter in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

The inheritance of epigenetic defects

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation in aging and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation decreases in aging but not in immortal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

In vitro senescence of human keratinocyte cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Maintenance of DNA methylation level in SV40-infected human fibroblasts during their in vitro limited proliferative life span

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation and epigenetic mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

DNA methylation in aging of mice

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of repetitive DNA sequences in the brain during aging of the rat

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Changes of the methylation pattern of the c-myc gene during in vitro aging of IMR90 human embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of the c-myc gene changes during aging process of mice

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Messenger RNA levels and methylation patterns of GAPDH and beta-actin genes in rat liver, spleen and brain in relation to aging

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Endogenous virus genomes become hypomethylated tissue--specifically during aging process of C57BL mice

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of CpG-island-containing genes in human sperm, fetal and adult tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Concordant methylation of the ER and N33 genes in glioblastoma multiforme.

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Effect of ageing on reactivation of the human X-linked HPRT locus

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Stability of DNA methylation of X-chromosome genes during aging

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Hypermethylation of chromosome 17P locus D17S5 in human prostate tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Epigenetic gene inactivation induced by a cis-acting methylation center

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Sp1 elements protect a CpG island from de novo methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Hormone replacement therapy, reproductive history, and colon cancer: a multicenter, case-control study in the United States

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Inactivation of gene expression in plants as a consequence of specific sequence duplication

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

Suppression of crossing-over by DNA methylation in Ascobolus

1 reference

https://api.crossref.org/works/10.1016%2FS1040-8428%2899%2900019-0

7 January 2021

10.1016/S1040-8428(99)00019-0

Identifiers

DOI

1 reference

29 July 2017

1 reference