(Q33787977)

29 July 2017

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness (English)

1 reference

29 July 2017

Michael Gotthardt

3

0 references

author name string

Bryan D Hudson

series ordinal

1

1 reference

PubMed ID

20026128

29 July 2017

Carlos G Hidalgo

series ordinal

2

1 reference

PubMed ID

20026128

29 July 2017

Henk L Granzier

series ordinal

4

1 reference

29 July 2017

21 December 2009

1 reference

Journal of Molecular and Cellular Cardiology

29 July 2017

1 reference

29 July 2017

48

1 reference

29 July 2017

972-978

1 reference

29 July 2017

5

1 reference

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase C in heart failure: a therapeutic target?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Endogenous calpain-3 activation is primarily governed by small increases in resting cytoplasmic [Ca2+] and is not dependent on stretch

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Hypertension and heart failure: a dysfunction of systole, diastole or both?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

PKC isozymes in chronic cardiac disease: possible therapeutic targets?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase C in cardiac disease and as a potential therapeutic target

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Molecular and integrated biology of thin filament protein phosphorylation in heart muscle

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

The giant protein titin: a major player in myocardial mechanics, signaling, and disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

PKC-alpha regulates cardiac contractility and propensity toward heart failure

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Cytoplasmic signaling pathways that regulate cardiac hypertrophy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

The giant protein titin. Emerging roles in physiology and pathophysiology

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Titins: giant proteins in charge of muscle ultrastructure and elasticity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Developmental changes in rat cardiac titin/connectin: transitions in normal animals and in mutants with a delayed pattern of isoform transition

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Towards a molecular understanding of the elasticity of titin.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2854275

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

30 October 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

The mechanically active domain of titin in cardiac muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

Cardiomyocyte Stiffness in Diastolic Heart Failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2009.12.006

10.1016/J.YJMCC.2009.12.006

7 January 2021

Identifiers

DOI

1 reference

release_bvpisbkn4baxveepgpy42uu3zy

29 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bvpisbkn4baxveepgpy42uu3zy

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

2854275

1 reference

29 July 2017

1 reference

PubMed ID

20026128