(Q33791286)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

0 references

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

9

Frank J Stewart

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

author name string

Yanni Lin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Matthew T Brown

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Harshavardhan Deshmukh

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Piyush Ranjan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Neha Sarode

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Brian M Wile

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Paula M Vertino

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Gang Bao

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

language of work or name

English

0 references

publication date

16 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

published in

Nucleic Acids Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

volume

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

page(s)

7473-7485

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 3.0 Unported

18 March 2020

copyright license

start time

5 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4066799/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Cas9 as a versatile tool for engineering biology

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Targeted genome modification of crop plants using a CRISPR-Cas system.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

DNA targeting specificity of RNA-guided Cas9 nucleases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Efficient genome editing in zebrafish using a CRISPR-Cas system

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

RNA-guided human genome engineering via Cas9

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Multiplex genome engineering using CRISPR/Cas systems

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

ENCODE data in the UCSC Genome Browser: year 5 update

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

FLASH assembly of TALENs for high-throughput genome editing

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

A rapid and general assay for monitoring endogenous gene modification

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Fast and accurate long-read alignment with Burrows-Wheeler transform

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

CRISPR/Cas, the immune system of bacteria and archaea

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Small CRISPR RNAs guide antiviral defense in prokaryotes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Indexing strategies for rapid searches of short words in genome sequences.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Chimeric nucleases stimulate gene targeting in human cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Heritable gene targeting in the mouse and rat using a CRISPR-Cas system.

4 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKU402

RNA-guided genome editing in plants using a CRISPR-Cas system.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066799

Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24838573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKU402

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24838573%20AND%20SRC:MED&resulttype=core&format=json