(Q33791683)

29 July 2017

title

Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation (English)

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29 July 2017

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6

David Baltimore

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29 July 2017

author name string

Parameswaran Ramakrishnan

1

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29 July 2017

Peter M Clark

2

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29 July 2017

Daniel E Mason

3

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29 July 2017

Eric C Peters

4

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29 July 2017

Linda C Hsieh-Wilson

5

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29 July 2017

publication date

27 August 2013

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29 July 2017

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29 July 2017

volume

6

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29 July 2017

issue

290

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29 July 2017

page(s)

ra75

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Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription

29 July 2017

cites work

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Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation

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O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells

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Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor

4 July 2018

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Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease

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4 July 2018

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4 July 2018

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4 July 2018

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Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis

4 July 2018

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c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

4 July 2018

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4 July 2018

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NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

4 July 2018

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Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-kappaB family member RelB.

4 July 2018

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O-GlcNAc regulates FoxO activation in response to glucose

4 July 2018

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Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation

4 July 2018

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Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel

4 July 2018

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Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

4 July 2018

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Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

4 July 2018

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Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

4 July 2018

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Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis

4 July 2018

1 reference

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Achieving antigen-specific immune regulation

4 July 2018

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Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability

4 July 2018

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Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease

4 July 2018

1 reference

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The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications

4 July 2018

1 reference

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Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

4 July 2018

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It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.

4 July 2018

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X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

4 July 2018

1 reference

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Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

The structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066889

4 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004097

Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation

21 January 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004097

Transcriptional Regulation of Type I Diabetes by NF-κB

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004097

YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation).

21 January 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004097

TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation

21 January 2018

1 reference

12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

12 December 2020

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

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12 December 2020

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

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12 December 2020

10.1126/SCISIGNAL.2004097

Identifiers

DOI

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29 July 2017

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29 July 2017

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